論文

査読有り
2013年1月

CCR6 Is Required for Epidermal Trafficking of gamma delta-T Cells in an IL-23-Induced Model of Psoriasiform Dermatitis

JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • Tomotaka Mabuchi
  • ,
  • Tej Pratap Singh
  • ,
  • Tomonori Takekoshi
  • ,
  • Guang-fu Jia
  • ,
  • Xuesong Wu
  • ,
  • Mandy C. Kao
  • ,
  • Ido Weiss
  • ,
  • Joshua M. Farber
  • ,
  • Sam T. Hwang

133
1
開始ページ
164
終了ページ
171
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/jid.2012.260
出版者・発行元
NATURE PUBLISHING GROUP

A subset of CC chemokine receptor-6(+) (CCR6(+)), gamma delta-low (GDL) Tcells that express Th17 cytokines in mouse skin participates in IL-23-induced psoriasiform dermatitis. We used CCR6-deficient (knockout, KO) and wild-type (WT) mice to analyze skin trafficking patterns of GDL T cells and function-blocking mAbs to determine the role of CCR6 in IL-23-mediated dermatitis. Herein, CCL20 was highly upregulated in IL-23-injected WT mouse ear skin as early as 24 hours after initial treatment, and large numbers of CCR6(+) cells were observed in the epidermis of IL-23-injected WT Mice. Anti-CCL20 mAbs reduced psoriasiform dermatitis and blocked recruitment of GDL T cells to the epidermis. In CCR6 KO mice, GDL T cells failed to accumulate in the epidermis after IL-23 treatment, but the total numbers of GDL T cells in the dermis of WT and CCR6 KO mice were equivalent. There was an similar to 70% reduction in the proportion of IL-22(+) GDL T cells in the dermis of CCR6 KO mice (vs. WT mice), suggesting that effector function and epidermal recruitment of GDLT ells are impaired in CCR6-deficient mice. Thus, these data show that CCR6 regulates epidermal trafficking of gamma delta-T-cell subsets in the skin and suggest the potential of CCR6 as a therapeutic target for psoriasis. Journal of investigative Dermatology (2013) 133, 164-171; doi :10.1038/jid.2012.260; published online 16 August 2012

Web of Science ® 被引用回数 : 81

リンク情報
DOI
https://doi.org/10.1038/jid.2012.260
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000312475500023&DestApp=WOS_CPL

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