論文

査読有り
2007年8月

Early inflammatory changes in the "perilesional skin" of psoriatic plaques: Is there interaction between dendritic cells and keratinocytes?

JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • Mayumi Komine
  • ,
  • Masaru Karakawa
  • ,
  • Tomonori Takekoshi
  • ,
  • Naoki Sakurai
  • ,
  • Yosaku Minatani
  • ,
  • Hiroshi Mitsui
  • ,
  • Yayoi Tada
  • ,
  • Hidehisa Saeki
  • ,
  • Akihiko Asahina
  • ,
  • Kunihiko Tamaki

127
8
開始ページ
1915
終了ページ
1922
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/sj.jid.5700799
出版者・発行元
NATURE PUBLISHING GROUP

Early inflammatory changes in psoriatic plaques were investigated immunohistochemically by studying the normal-appearing skin adjacent to the plaques (perilesional skin), lesional skin, and distant uninvolved skin from psoriasis patients. Perilesional epidermis contained numerous CD1a-positive Langerhans cells, some of which expressed HLA-DR, CD83, CD80, and CD86, at the same time expressing Langerin. There were also numerous CD83-positive, CD11c-positive, Langerin-negative clendritic cells (DCs) in the epidermal-dermal junction of perilesional skin. CD3-positive T lymphocytes were sparse in the perilesional skin. Perilesional epidermis expressed keratin K6 and K16, inflammatory keratins, and C/EBP beta, a transcription factor related to inflammatory cytokines. Our results demonstrated the abundant distribution of activated DCs in the perilesional skin of psoriatic plaques, where early inflammatory changes occur in the epidermal keratinocytes, which suggests their involvement in the provocation of epidermal inflammation in the perilesional epidermis and further pathogenic roles in the formation of psoriatic plaques.

Web of Science ® 被引用回数 : 38

リンク情報
DOI
https://doi.org/10.1038/sj.jid.5700799
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/17446902
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000248591200024&DestApp=WOS_CPL

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