論文

査読有り
2002年11月

Polymorphisms of vitamin D receptor gene in Japanese patients with psoriasis vulgaris

JOURNAL OF DERMATOLOGICAL SCIENCE
  • H Saeki
  • ,
  • N Asano
  • ,
  • Y Tsunemi
  • ,
  • T Takekoshi
  • ,
  • M Kishimoto
  • ,
  • H Mitsui
  • ,
  • Y Tada
  • ,
  • H Torii
  • ,
  • M Komine
  • ,
  • A Asahina
  • ,
  • K Tamaki

30
2
開始ページ
167
終了ページ
171
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/S0923-1811(02)00073-7
出版者・発行元
ELSEVIER SCI IRELAND LTD

We examined polymorphisms of vitamin D receptor (VDR) gene in Japanese patients with psoriasis vulgaris (PsV). We also studied the association between VDR gene polymorphisms and the response to vitamin D (VD) topical treatment in psoriatic patients. FokI, BsmI, ApaI and TaqI genotypes were determined by restriction fragment patterns in patients (n = 115) and controls (n = 69). In addition, 54 psoriatic patients were divided into two groups in terms of their response to VD (tacalcitol) topical treatment: non-responsive (n = 30) and responsive (n = 24) patients. The frequencies of B allele and t allele were lower in patients than in controls (9 vs. 19%: p < 0.01, 7 vs. 14%: p < 0.05, respectively). In regard to response to VD treatment, F allele was lower in non-responsive patients than in controls (47 vs. 64%, p < 0.05). We show that polymorphisms of VDR gene are associated with Japanese patients with PsV., Allelic variance in the VDR gene or other genes in linkage disequilibrium with this gene might predispose to the development of PsV. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

Web of Science ® 被引用回数 : 45

リンク情報
DOI
https://doi.org/10.1016/S0923-1811(02)00073-7
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/12413773
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000179737500011&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/S0923-1811(02)00073-7
  • ISSN : 0923-1811
  • PubMed ID : 12413773
  • Web of Science ID : WOS:000179737500011

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