論文

国際誌
2020年4月25日

Structural Changes in Hippocampal Subfields in Patients with Continuous Remission of Drug-Naive Major Depressive Disorder.

International journal of molecular sciences
  • Asuka Katsuki
  • ,
  • Keita Watanabe
  • ,
  • LeHoa Nguyen
  • ,
  • Yuka Otsuka
  • ,
  • Ryohei Igata
  • ,
  • Atsuko Ikenouchi
  • ,
  • Shingo Kakeda
  • ,
  • Yukunori Korogi
  • ,
  • Reiji Yoshimura

21
9
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3390/ijms21093032

OBJECTIVE: Hippocampal volume is reduced in patients with major depressive disorder (MDD) compared with healthy controls. The hippocampus is a limbic structure that has a critical role in MDD. The aim of the present study was to investigate the changes in the volume of the hippocampus and its subfields in MDD patients who responded to antidepressants and subsequently were in continuous remission. SUBJECTS AND METHODS: Eighteen patients who met the following criteria were enrolled in the present study: the DSM-IV-TR criteria for MDD, drug-naïve at least 8 weeks or more, scores on the 17-items of Hamilton Rating Scale for Depression (HAMD) of 14 points or more, and antidepressant treatment response within 8 weeks and continuous remission for at least 6 months. All participants underwent T1-weighted structural MRI and were treated with antidepressants for more than 8 weeks. We compared the volumes of the hippocampus, including its subfields, in responders at baseline to the volumes at 6 months. The volumes of the whole hippocampus and the hippocampal subfields were measured using FreeSurfer v6.0. RESULTS: The volumes of the left cornu Ammonis (CA) 3 (p = 0.016) and the granule cell layer of the dentate gyrus (GC-DG) region (p = 0.021) were significantly increased after 6 months of treatment compared with those at baseline. CONCLUSIONS: Increases in volume was observed in MDD patients who were in remission for at least 6 months.

リンク情報
DOI
https://doi.org/10.3390/ijms21093032
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32344826
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246866
ID情報
  • DOI : 10.3390/ijms21093032
  • PubMed ID : 32344826
  • PubMed Central 記事ID : PMC7246866

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