2000年12月15日
Regulation of Wee1 kinase in response to protein synthesis inhibition
FEBS Letters
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- ,
- ,
- ,
- 巻
- 486
- 号
- 3
- 開始ページ
- 305
- 終了ページ
- 309
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/S0014-5793(00)02299-7
To investigate the mechanism coupling growth (protein synthesis) with cell division, we examined the relationship between the tyrosine kinase Wee1 that inhibits Cdc2-Cdc13 mitosis-inducing kinase by phosphorylating it, and protein synthesis inhibition in fission yeast. The wee1-50 mutant showed supersensitivity to protein synthesis inhibitor, cycloheximide. Wee1 was essential for the G2 delay upon a partial inhibition of protein synthesis. Indeed, the protein synthesis inhibition caused an increase in the Wee1 protein by the Sty1/Spc1 MAPK-dependent transcriptional and the Sty1/Spc1 MAPK-independent post-transcriptional regulations. Further, the results indicated that the post-transcriptional regulation is important for the G2 delay. Copyright (C) 2000 Federation of European Biochemical Societies.
- リンク情報
- ID情報
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- DOI : 10.1016/S0014-5793(00)02299-7
- ISSN : 0014-5793
- CiNii Articles ID : 10010560539
- PubMed ID : 11119724
- SCOPUS ID : 0034672545