1999年1月
Functional analysis of the promoter of the yeast SNQ2 gene encoding a multidrug resistance transporter that confers the resistance to 4-nitroquinoline N-oxide
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
- ,
- ,
- 巻
- 63
- 号
- 1
- 開始ページ
- 162
- 終了ページ
- 167
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1271/bbb.63.162
- 出版者・発行元
- TAYLOR & FRANCIS LTD
The yeast gene SNQ2, which encodes a multidrug resistance ABC superfamily protein, is required for resistance to the mutagen 4-nitroquinoline N-oxide (4-NQO). The expression of the SNQ2 gene is under the control of a regulatory network that involves the transcription factor Yrr1p, as well as Pdr1p/Pdr3p (Cui et al., Mel. Microbiol., 29, 1307-1315 (1998)). By 5'-deletion analysis of the promoter by using SNQ2-lacZ fusion constructs, four regions: -745 to -639 (region I), -639 to -578 (region II), -548 to -533 (region III) and -533 to -485 (region IV) were found to be important for SNQ2 expression. Genetic analysis suggested that the site in region IV was responsible for the Yrr1p-mediated SNQ2 expression. A consensus motif known for the binding of Pdr1p/Pdr3p (PDRE) was not found in region IV.
- リンク情報
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- DOI
- https://doi.org/10.1271/bbb.63.162
- CiNii Articles
- http://ci.nii.ac.jp/naid/110002679358
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/10052137
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000078430500025&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1271/bbb.63.162
- ISSN : 0916-8451
- eISSN : 1347-6947
- CiNii Articles ID : 110002679358
- PubMed ID : 10052137
- Web of Science ID : WOS:000078430500025