MISC

1999年1月

Functional analysis of the promoter of the yeast SNQ2 gene encoding a multidrug resistance transporter that confers the resistance to 4-nitroquinoline N-oxide

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
  • ZF Cui
  • ,
  • D Hirata
  • ,
  • T Miyakawa

63
1
開始ページ
162
終了ページ
167
記述言語
英語
掲載種別
DOI
10.1271/bbb.63.162
出版者・発行元
TAYLOR & FRANCIS LTD

The yeast gene SNQ2, which encodes a multidrug resistance ABC superfamily protein, is required for resistance to the mutagen 4-nitroquinoline N-oxide (4-NQO). The expression of the SNQ2 gene is under the control of a regulatory network that involves the transcription factor Yrr1p, as well as Pdr1p/Pdr3p (Cui et al., Mel. Microbiol., 29, 1307-1315 (1998)). By 5'-deletion analysis of the promoter by using SNQ2-lacZ fusion constructs, four regions: -745 to -639 (region I), -639 to -578 (region II), -548 to -533 (region III) and -533 to -485 (region IV) were found to be important for SNQ2 expression. Genetic analysis suggested that the site in region IV was responsible for the Yrr1p-mediated SNQ2 expression. A consensus motif known for the binding of Pdr1p/Pdr3p (PDRE) was not found in region IV.

リンク情報
DOI
https://doi.org/10.1271/bbb.63.162
CiNii Articles
http://ci.nii.ac.jp/naid/110002679358
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/10052137
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000078430500025&DestApp=WOS_CPL
ID情報
  • DOI : 10.1271/bbb.63.162
  • ISSN : 0916-8451
  • eISSN : 1347-6947
  • CiNii Articles ID : 110002679358
  • PubMed ID : 10052137
  • Web of Science ID : WOS:000078430500025

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