2017年11月8日
Nonhuman Primate Optogenetics: Recent Advances and Future Directions.
The Journal of neuroscience : the official journal of the Society for Neuroscience
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- 巻
- 37
- 号
- 45
- 開始ページ
- 10894
- 終了ページ
- 10903
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1523/JNEUROSCI.1839-17.2017
- 出版者・発行元
- SOC NEUROSCIENCE
Optogenetics is the use of genetically coded, light-gated ion channels or pumps (opsins) for millisecond resolution control of neural activity. By targeting opsin expression to specific cell types and neuronal pathways, optogenetics can expand our understanding of the neural basis of normal and pathological behavior. To maximize the potential of optogenetics to study human cognition and behavior, optogenetics should be applied to the study of nonhuman primates (NHPs). The homology between NHPs and humans makes these animals the best experimental model for understanding human brain function and dysfunction. Moreover, for genetic tools to have translational promise, their use must be demonstrated effectively in large, wild-type animals such as Rhesus macaques. Here, we review recent advances in primate optogenetics. We highlight the technical hurdles that have been cleared, challenges that remain, and summarize how optogenetic experiments are expanding our understanding of primate brain function.
- リンク情報
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- DOI
- https://doi.org/10.1523/JNEUROSCI.1839-17.2017
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/29118219
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678022
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000414662100015&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1523/JNEUROSCI.1839-17.2017
- ISSN : 0270-6474
- PubMed ID : 29118219
- PubMed Central 記事ID : PMC5678022
- Web of Science ID : WOS:000414662100015