2010年2月
Inhibitory effect of anthraquinones isolated from the Noni (Morinda citrifolia) root on animal A-, B- and Y-families of DNA polymerases and human cancer cell proliferation
FOOD CHEMISTRY
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- 巻
- 118
- 号
- 3
- 開始ページ
- 725
- 終了ページ
- 730
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.foodchem.2009.05.053
- 出版者・発行元
- ELSEVIER SCI LTD
During the course of our studies to develop new uses for the Noni (Morinda citrifolia) root, 10 anthraquinones, rubiadin (1), rubiadin 1-methyl ether (2), lucidin (3), damnacanthol (4), 1,3-dihydroxy-2-methoxymethylanthraquinone (5), 3-hydroxy-1-methoxy-2-methoxymethylanthraquinone (6), nordamnacanthal (7), damnacanthal (8), sorandidiol (9) and morindone (10), were isolated. Compounds 5, 6,7, 8 and 10 exhibited remarkable inhibition against the activities of animal pols, and compound 10 was the strongest inhibitor in the anthraquinones investigated. Among mammalian pols, compound 10 inhibited the pol activities of A- (pol gamma), B- (pols alpha, delta and epsilon) and Y- (pols eta, iota and kappa) families, but did not influence the activities of X-family pols (pols beta, lambda and terminal deoxynucleotidyl transferase). The tendency of pol inhibition showed a positive correlation with the suppression of human colon cancer cell HCT116 growth. These results suggested that the Noni root containing anthraquinones may be used as an anticancer functional food. (C) 2009 Elsevier Ltd. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.foodchem.2009.05.053
- ISSN : 0308-8146
- eISSN : 1873-7072
- CiNii Articles ID : 80020734392
- Web of Science ID : WOS:000270492800036