HIROTA Koki

J-GLOBAL         Last updated: Oct 21, 2019 at 08:42
 
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Name
HIROTA Koki
URL
http://doctor-koki.sakura.ne.jp/
Affiliation
University of Toyama
Section
Graduate School of Medicine and Pharmaceutical Sciences for Research, Department of Anesthesiology
Job title
Associate Professor
Degree
M. D., Ph. D.
Research funding number
30218854

Profile

Koki Hirota received his M.D. and Ph.D. degrees from University of Toyama, Toyama, Japan, in 1984 and 1988, respectively. In 1990, he was awarded the Yamamura Prize from Japanese Society of Anesthesiologists. From 1992 to 1994, he was a Research Fellow at the University of Calgary, Calgary, AB, Canada, under the direction of Professor S. H. Roth (Departments of Pharmacology and Anesthesia). Currently, he works as an Associate Professor of Anesthesiology and as a Clinical Professor at University Hospital, University of Toyama. He has been interested in mechanisms of anesthesia in the central nervous system, studying the actions of general anesthetics on hippocampal synaptic transmission using brain slice preparations. He participated in symposia as a Chair, as in the Mechanism of Anesthesia Conference and in the Japanese Society of Anesthesiologists, and he organized the International Conference on Mechanisms of Anesthesia (MAC2010, University of Toronto, Canada) as a Scientific Adviser. He serves as Associate Editorial Board in Journal of Anesthesia. He has published books entitled "Mysteries in Anesthesia: Unlock the Magic in Operating Room" in 2012, and "Odysseys in Anesthesia Labyrinth" in 2018.

Research Interests

 
 

Research Areas

 
 

Academic & Professional Experience

 
2001
 - 
Today
Clinical Professor, Toyama University Hospital
 
2001
 - 
Today
Associate Professor, Department of Anesthesiology, University of Toyama
 
1994
 - 
2001
Assistant Professor, Toyama Medical & Pharmaceutical University
 
1992
 - 
1994
Research Fellow, University of Calgary
 
1991
 - 
1992
Assistant Professor, Toyama Medical & Pharmaceutical University
 

Education

 
1984
 - 
1988
Graduate School of Medicine, University of Toyama
 
1978
 - 
1984
Faculty of Medicine, University of Toyama
 

Committee Memberships

 
Jan 2014
 - 
Today
Journal of Anesthesia  Associate Editorial Board Member
 
2010
 - 
Today
ISRN Anesthesiology  Editorial Board Member
 
2009
 - 
2010
International Conference on Mechanisms of Anesthesia  Scientific Adviser
 

Awards & Honors

 
2017
Best Reviewer, Journal of Anesthesia, Japanese Society of Anesthesiologists
 
2016
Best Reviewer, Journal of Anesthesia, Japanese Society of Anesthesiologists
 
May 2013
The most valuable presentation award, Japanese Society of Anesthesiologists
Winner: Rika Sasaki, Koki HIrota, Masana Yamada, Mitsuaki Yamazaki
 
1991
The Yamamura Prize, Japanese Society of Anesthesiologists
Winner: Koki Hirota, Yusuke Ito, Shougo Kuze, Ysunori Momose
 

Published Papers

 
Inhibitory actions of general anesthetics on hippocampal CA1 neurons modified by activation of amygdala circuitry are demonstrated on the novel amygdala-hippocampal slice preparation
HIROTA Koki, SASAKI Rika, et al.
Toxicology In Vitro   60 173-179   2019   [Refereed]
HIROTA Koki, SASAKI Rika, et al.
Toxicology In Vitro   26(6) 872-877   Sep 2012   [Refereed]
[Electrophysiological approach to mechanisms for actions of general anesthetics].
Hirota K, Sasaki R
Masui. The Japanese journal of anesthesiology   60(5) 574-581   May 2011   [Refereed]
Dementia Enhances Inhibitory Actions of General Anesthetics in Hippocampal Synaptic Transmission
HIROTA Koki, SASAKI Rika, et al.
ISRN Anesthesiology      2011   [Refereed]

Misc

 
Electrophysiological approach to the mechanism for the modulation of anesthetic action
HIROTA Koki, SASAKI Rika
Journal of Clinical Anesthesia (Japan)   37(4) 603-614   Apr 2013   [Invited]
Suzuki A, Toyama Y, Katsumi N, Kunisawa T, Sasaki R, Hirota K
Anaesthesia   63 641-647   2008
Asahi T, Hirota K, Sasaki R, Roth SH, Yamazaki M
Anesthesia & Analgesia   102 772-778   2006
Sasaki R, Hirota K, Roth SH, Yamazaki M
British Journal of Anaesthesia   94 486-491   2005

Books etc

 
Mysteries in Anesthesia: Unlock the Magic in Operating Room
HIROTA Koki
Kagaku Dojin, Kyoto, Japan   Jul 2012   
Basic and Systemic Mechanisms of Anesthesia
Elsevier, Amsterdam, The Netherlands   2005   
Molecular and basic mechanisms of anesthesia
Pabst Science Publishers, Lengerich, Germany   2002   

Conference Activities & Talks

 
Effects of general anesthetics on excitatory and inhibitory synaptic pathways of hippocampus in vitro
HIROTA Koki
International Conference on Basic and Systemic Mechanisms of Anesthesia   Feb 2005   

Research Grants & Projects

 
Does enriched environment improve quality of anesthesia? Neuroscientific research in amygdala/hippocampus
The Ministry of Education: Grant-in-Aid for Scientific Research (C)
Project Year: Apr 2019 - Mar 2022
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2005 - 2008    Investigator(s): Hirota KOKI
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2003 - 2004    Investigator(s): Koki HIROTA
We compared age-related modifications of the effects of general anesthetics in area CA1 of hippocampal slices at 4 weeks (younger group) and 18 weeks (elder group) of age.Method. Transverse hippocampal slices (400 μm) were prepared from male Wista...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 1999 - 2002    Investigator(s): Koki HIROTA
Although previous clinical reports suggested the prophylactic effects of hypothermia and/or general anesthetics against cerebral ischemia, the cellular mechanisms by which hypothermia and/or anesthetics protect brain tissue against hypoxia remain ...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 1996 - 1998    Investigator(s): Yusuke ITO
There are several possible mechanisms of general anaesthesia including the change of conductance in ionic channels. increased membrane fluidity, and altered responses to neurotransmitters . Ethanol is known to enhance membrane fluidity, and in lip...