キャメロンドナルド (Donald Cameron) - マイポータル

基本情報

所属: 東京大学定量生命科学研究所

研究者番号: 61011961
ORCID iD: https://orcid.org/0000-0002-3175-6965
J-GLOBAL ID: 202401014338977570
researchmap会員ID: R000076891

研究キーワード

研究分野

経歴

2018年 - 2024年

Karolinska Institutet, Dept. of Cell and Molecular Biology (Postdoctoral Researcher)
2011年 - 2013年

Peter MacCallum Cancer Centre, Oncogenic Signalling and Growth Control Program (Research Assistant)

学歴

2014年 - 2018年

University of Melbourne, Peter MacCallum Cancer Centre, PhD
2010年 - 2010年

The University of Melbourne, Peter MacCallum Cancer Centre, Bachelor of Science (Honours)
2005年 - 2009年

The University of Melbourne, Bachelor of Science/Bachelor of Commerce

論文

CX-5461 Preferentially Induces Top2α-Dependent DNA Breaks at Ribosomal DNA Loci.

Donald P Cameron, Jirawas Sornkom, Sameerh Alsahafi, Denis Drygin, Gretchen Poortinga, Grant A McArthur, Nadine Hein, Ross Hannan, Konstantin I Panov

Biomedicines 12(7) 2024年7月8日
Coinhibition of topoisomerase 1 and BRD4-mediated pause release selectively kills pancreatic cancer via readthrough transcription.

Donald P Cameron, Jan Grosser, Swetlana Ladigan, Vladislav Kuzin, Evanthia Iliopoulou, Anika Wiegard, Hajar Benredjem, Kathryn Jackson, Sven T Liffers, Smiths Lueong …

Science advances 9(41) eadg5109 2023年10月13日
TOP1 CAD-seq: A protocol to map catalytically engaged topoisomerase 1 in human cells.

Vladislav Kuzin, Anika Wiegard, Donald P Cameron, Laura Baranello

STAR protocols 3(3) 101581-101581 2022年9月16日
MYCMI-7: A Small MYC-Binding Compound that Inhibits MYC: MAX Interaction and Tumor Growth in a MYC-Dependent Manner.

Alina Castell, Qinzi Yan, Karin Fawkner, Wesam Bazzar, Fan Zhang, Malin Wickström, Mohammad Alzrigat, Marcela Franco, Cecilia Krona, Donald P Cameron …

Cancer research communications 2(3) 182-201 2022年3月
MYC assembles and stimulates topoisomerases 1 and 2 in a "topoisome".

Subhendu K Das, Vladislav Kuzin, Donald P Cameron, Suzanne Sanford, Rajiv Kumar Jha, Zuqin Nie, Marta Trullols Rosello, Ronald Holewinski, Thorkell Andresson, Jan Wisniewski …

Molecular cell 82(1) 140-158 2022年1月6日
Topoisomerase 1 activity during mitotic transcription favors the transition from mitosis to G1.

Anika Wiegard, Vladislav Kuzin, Donald P Cameron, Jan Grosser, Michele Ceribelli, Rashid Mehmood, Roberto Ballarino, Francesco Valant, Radosław Grochowski, Ivana Karabogdan …

Molecular cell 81(24) 5007-5024 2021年12月16日
Deficiency of Polη in Saccharomyces cerevisiae reveals the impact of transcription on damage-induced cohesion.

Pei-Shang Wu, Jan Grosser, Donald P Cameron, Laura Baranello, Lena Ström

PLoS genetics 17(9) e1009763 2021年9月
The Epstein-Barr virus deubiquitinating enzyme BPLF1 regulates the activity of topoisomerase II during productive infection.

Jinlin Li, Noemi Nagy, Jiangnan Liu, Soham Gupta, Teresa Frisan, Thomas Hennig, Donald P Cameron, Laura Baranello, Maria G Masucci

PLoS pathogens 17(9) e1009954 2021年9月
Analysis of Myc Chromatin Binding by Calibrated ChIP-Seq Approach.

Donald P Cameron, Vladislav Kuzin, Laura Baranello

Methods in molecular biology (Clifton, N.J.) 2318 161-185 2021年
rDNA Chromatin Activity Status as a Biomarker of Sensitivity to the RNA Polymerase I Transcription Inhibitor CX-5461.

Jinbae Son, Katherine M Hannan, Gretchen Poortinga, Nadine Hein, Donald P Cameron, Austen R D Ganley, Karen E Sheppard, Richard B Pearson, Ross D Hannan, Elaine Sanij

Frontiers in cell and developmental biology 8 568-568 2020年
First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Cancers: Results of a Phase I Dose-Escalation Study.

Amit Khot, Natalie Brajanovski, Donald P Cameron, Nadine Hein, Kylee H Maclachlan, Elaine Sanij, John Lim, John Soong, Emma Link, Piers Blombery …

Cancer discovery 9(8) 1036-1049 2019年8月
Changes in long-range rDNA-genomic interactions associate with altered RNA polymerase II gene programs during malignant transformation.

Jeannine Diesch, Megan J Bywater, Elaine Sanij, Donald P Cameron, William Schierding, Natalie Brajanovski, Jinbae Son, Jirawas Sornkom, Nadine Hein, Maurits Evers …

Communications biology 2 39-39 2019年
Palbociclib synergizes with BRAF and MEK inhibitors in treatment naïve melanoma but not after the development of BRAF inhibitor resistance.

Claire A Martin, Carleen Cullinane, Laura Kirby, Shatha Abuhammad, Emily J Lelliott, Kelly Waldeck, Richard J Young, Natalie Brajanovski, Donald P Cameron, Rachael Walker …

International journal of cancer 142(10) 2139-2152 2018年5月15日
Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population.

Nadine Hein, Donald P Cameron, Katherine M Hannan, Nhu-Y N Nguyen, Chun Yew Fong, Jirawas Sornkom, Meaghan Wall, Megan Pavy, Carleen Cullinane, Jeannine Diesch …

Blood 129(21) 2882-2895 2017年5月25日
Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene

Marcus Lefebure, Richard W. Tothill, Elizabeth Kruse, Edwin D. Hawkins, Jake Shortt, Geoffrey M. Matthews, Gareth P. Gregory, Benjamin P. Martin, Madison J. Kelly, Izabela Todorovski …

Nature Communications 8(1) 2017年3月6日
Selective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis.

Louise E Kerry, Elaine E Pegg, Donald P Cameron, James Budzak, Gretchen Poortinga, Katherine M Hannan, Ross D Hannan, Gloria Rudenko

PLoS neglected tropical diseases 11(3) e0005432 2017年3月
The Dual Inhibition of RNA Pol I Transcription and PIM Kinase as a New Therapeutic Approach to Treat Advanced Prostate Cancer.

Richard J Rebello, Eric Kusnadi, Donald P Cameron, Helen B Pearson, Analia Lesmana, Jennifer R Devlin, Denis Drygin, Ashlee K Clark, Laura Porter, John Pedersen …

Clinical cancer research : an official journal of the American Association for Cancer Research 22(22) 5539-5552 2016年11月15日
Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling.

Jaclyn Quin, Keefe T Chan, Jennifer R Devlin, Donald P Cameron, Jeannine Diesch, Carleen Cullinane, Jessica Ahern, Amit Khot, Nadine Hein, Amee J George …

Oncotarget 7(31) 49800-49818 2016年8月2日
A phase 1, open-label, dose escalation, safety, PK and PD study of a first in class Pol1 inhibitor (CX-5461) in patients with advanced hematologic malignancies (HM).

Simon J Harrison, Amit Khot, Natalie Brajanovski, Don Cameron, Nadine Hein, Grant A. McArthur, John K.C. Lim, Sean O'Brien, David M Ryckman, Grace I Yu …

Journal of Clinical Oncology 33(15{\_}suppl) e22212-e22212 2015年5月
A novel role for the Pol I transcription factor UBTF in maintaining genome stability through the regulation of highly transcribed Pol II genes.

Elaine Sanij, Jeannine Diesch, Analia Lesmana, Gretchen Poortinga, Nadine Hein, Grace Lidgerwood, Donald P Cameron, Jason Ellul, Gregory J Goodall, Lee H Wong …

Genome research 25(2) 201-12 2015年2月

もっとみる

所属学協会

2024年 - 現在

日本分子生物学会