2012年4月
N-acetylglucosamine increases symptoms and fungal burden in a murine model of oral candidiasis
Medical Mycology
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回数 : 72
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- 巻
- 50
- 号
- 3
- 開始ページ
- 252
- 終了ページ
- 258
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.3109/13693786.2011.598194
- 出版者・発行元
- INFORMA HEALTHCARE
The amino sugar N-acetylglucosamine (GlcNAc) is an in vitro inducer of the hyphal mode of growth of the opportunistic pathogen Candida albicans. The development of hyphae by C. albicans is considered to contribute to the pathogenesis of mucosal oral candidiasis. GlcNAc is also a commonly used nutritional supplement for the self-treatment of conditions such as arthritis. To date, no study has investigated whether ingestion of GlcNAc has an effect on the in vivo growth of C. albicans or the pathogenesis of a C. albicans infection. Using a murine model of oral candidiasis, we have found that administration of GlcNAc, but not glucose, increased oral symptoms of candidiasis and fungal burden. Groups of mice were given GlcNAc in either water or in a viscous carrier, i.e., 1% methylcellulose. There was a dose-dependent relationship between GlcNAc concentration and the severity of oral symptoms. Mice given the highest dose of GlcNAc, 45.2 mM, also showed a significant increase in fungal burden, and increased histological evidence of infection compared to controls given water alone. We propose that ingestion of GlcNAc, as a nutritional supplement, may have an impact on oral health in people susceptible to oral candidiasis. © 2012 ISHAM.
- リンク情報
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- DOI
- https://doi.org/10.3109/13693786.2011.598194
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/21859389
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000301536200004&DestApp=WOS_CPL
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84858381342&origin=inward 本文へのリンクあり
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84858381342&origin=inward
- ID情報
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- DOI : 10.3109/13693786.2011.598194
- ISSN : 1369-3786
- eISSN : 1460-2709
- PubMed ID : 21859389
- SCOPUS ID : 84858381342
- Web of Science ID : WOS:000301536200004