論文

査読有り
2016年11月

Does the routine handling affect the phenotype of disease model mice?

JAPANESE JOURNAL OF VETERINARY RESEARCH
  • Maiko Ono
  • ,
  • Hayato Sasaki
  • ,
  • Kenichi Nagasaki
  • ,
  • Daisuke Torigoe
  • ,
  • Osamu Ichii
  • ,
  • Nobuya Sasaki
  • ,
  • Takashi Agui

64
4
開始ページ
265
終了ページ
271
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.14943/jjvr.64.4.265
出版者・発行元
HOKKAIDO UNIV

The three different mouse handling methods, picking up by tails, tunnels, and open hands were performed using the ICGN glomerulonephritis mouse and the severity of symptoms was evaluated. The handling groups exhibited a tendency of more severe symptoms than the non-handling control group. Female mice handled by their tails showed significantly more severe symptoms than the control group. In addition, we subjected the normal laboratory mice, C57BL/6 and BALB/c mice to tail and tunnel handling to assess the stress conditions. The plasma corticosterone level in the tail-handled mice was higher than that in control mice. These results indicate that handling causes stress and may affect the phenotype of disease model mice.

Web of Science ® 被引用回数 : 8

リンク情報
DOI
https://doi.org/10.14943/jjvr.64.4.265
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29786176
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000390082700005&DestApp=WOS_CPL
ID情報
  • DOI : 10.14943/jjvr.64.4.265
  • ISSN : 0047-1917
  • PubMed ID : 29786176
  • Web of Science ID : WOS:000390082700005

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