論文

査読有り
2016年1月

QTL analysis of modifiers for pigmentary disorder in rats carrying Ednrb(sl) mutations

SCIENTIFIC REPORTS
  • Jieping Huang
  • ,
  • Ruihua Dang
  • ,
  • Daisuke Torigoe
  • ,
  • Anqi Li
  • ,
  • Chuzhao Lei
  • ,
  • Nobuya Sasaki
  • ,
  • Jinxi Wang
  • ,
  • Takashi Agui

6
開始ページ
19697
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/srep19697
出版者・発行元
NATURE PUBLISHING GROUP

Pigmentary variation in animals has been studied because of its application in genetics, evolution, and developmental biology. The large number of known color loci provides rich resource to elucidate the functional pigmentary system. Nonetheless, more color loci remain to be identified. In our previous study, we revealed that two different strains, namely, AGH rats and LEH rats, but which had the same null mutation of the Ednrb gene (Ednrb(sl)) showed markedly different pigmented coat ratio. This result strongly suggested that the severity of pigment abnormality was modified by genetic factor(s) in each strain. To elucidate the modifier locus of pigment disorder, we carried out whole-genome scanning for quantitative trait loci (QTLs) on 149 F2 (AGH-Ednrb(sl) x LEH-Ednrb(sl)) rats. A highly significant QTL, constituting 26% of the total pigmentation phenotype variance, was identified in a region around D7Got23 on chromosome (Chr) 7. In addition, investigation on epistatic interaction revealed significant interactions between D7Got23 and D3Rat78 and between D7Got23 and D14Mit4. Results suggested that a modified locus on Chr 7 was mainly responsible for the variance of pigmentary disorder between AGH-Ednrb(sl) rats and LEH-Ednrb(sl) rats, and two modifier loci showing epistatic interaction may, in part, influence pigment phenotype.


リンク情報
DOI
https://doi.org/10.1038/srep19697
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26796131
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000368687000001&DestApp=WOS_CPL
ID情報
  • DOI : 10.1038/srep19697
  • ISSN : 2045-2322
  • PubMed ID : 26796131
  • Web of Science ID : WOS:000368687000001

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