論文

査読有り
2015年5月

Identification of multiple genetic loci in the mouse controlling immobility time in the tail suspension and forced swimming tests

JAPANESE JOURNAL OF VETERINARY RESEARCH
  • Ahmed F. Abou-Elnaga
  • ,
  • Daisuke Torigoe
  • ,
  • Mohamed M. Fouda
  • ,
  • Ragab A. Darwish
  • ,
  • Usama A. Abou-Ismail
  • ,
  • Masami Morimatsu
  • ,
  • Takashi Agui

63
2
開始ページ
53
終了ページ
62
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.14943/jjvr.63.2.53
出版者・発行元
HOKKAIDO UNIV

Depression is one of the most famous psychiatric disorders in humans in all over the countries and considered a complex neurobehavioral trait and difficult to identify causal genes. Tail suspension test (TST) and forced swimming test (FST) are widely used for assessing depression-like behavior and antidepressant activity in mice. A variety of antidepressant agents are known to reduce immobility time in both TST and FST. To identify genetic determinants of immobility duration in both tests, we analyzed 101 F-2 mice from an intercross between C57BL/6 and DBA/2 strains. Quantitative trait locus (QTL) mapping using 106 microsatellite markers revealed three loci (two significant and one suggestive) and five suggestive loci controlling immobility time in the TST and FST, respectively. Results of QTL analysis suggest a broad description of the genetic architecture underlying depression, providing underpinnings for identifying novel molecular targets for antidepressants to clear the complex genetic mechanisms of depressive disorders.

Web of Science ® 被引用回数 : 2

リンク情報
DOI
https://doi.org/10.14943/jjvr.63.2.53
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26164874
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000356400700001&DestApp=WOS_CPL
ID情報
  • DOI : 10.14943/jjvr.63.2.53
  • ISSN : 0047-1917
  • PubMed ID : 26164874
  • Web of Science ID : WOS:000356400700001

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