論文

査読有り
2012年8月

Lymphopenia in Ednrb-deficient rat was strongly modified by genetic background

BIOMEDICAL RESEARCH-TOKYO
  • Ruihua Dang
  • ,
  • Nobuya Sasaki
  • ,
  • Tomohiro Nishino
  • ,
  • Moe Nakanishi
  • ,
  • Daisuke Torigoe
  • ,
  • Takashi Agui

33
4
開始ページ
249
終了ページ
253
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.2220/biomedres.33.249
出版者・発行元
BIOMEDICAL RESEARCH PRESS LTD

The endothelin signaling pathway plays an important role in the migration, proliferation, and differentiation of neural crest cells. Mutations in the gene encoding the endothelin receptor type B (EDNRB) cause three symptoms: aganglionosis, pigmented disorder and hearing loss. In addition, the Ednrb null mice show abnormal splenic microarchitecture with lymphopenia. In this study, we examined whether similar phenotypes are reproduced in three Ednrb-null rat strains that we established previously. AGH-Ednrb(sl/sl) strain showed a low white blood cell count, significant size reduction and abnormal microarchitecture of spleen. Thymus displayed a marked reduction in the size, but maintained a normal CD4/CD8 ratio. In contrast, splenic cellularity was reduced to < 15%, and splenic B and T cell numbers were reduced, showing a splenic lymphopenia. Interestingly, Ednrb-null rats in the LE and F344 genetic background did not show these abnormalities. These data show that proper T and B cell development is dependent on the endothelin signaling pathway, however, modifier gene(s) might be differentially expressed in these strain to modulate or compensate for the effect of the Ednrb deficiency.

Web of Science ® 被引用回数 : 5

リンク情報
DOI
https://doi.org/10.2220/biomedres.33.249
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/22975636
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000308773000007&DestApp=WOS_CPL
ID情報
  • DOI : 10.2220/biomedres.33.249
  • ISSN : 0388-6107
  • PubMed ID : 22975636
  • Web of Science ID : WOS:000308773000007

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