論文

査読有り
2012年3月

Anatomic Modifications in the Enteric Nervous System of JF1 Mice with the Classic Piebald Mutation

JOURNAL OF VETERINARY MEDICAL SCIENCE
  • Ruihua Dang
  • ,
  • Nobuya Sasaki
  • ,
  • Daisuke Torigoe
  • ,
  • Takashi Agui

74
3
開始ページ
391
終了ページ
394
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1292/jvms.11-0447
出版者・発行元
JAPAN SOC VET SCI

The Japanese Fancy Mouse 1 (JF1) has a characteristic coat color similar to a very old mutant, piebald. The mutation in JF1 and the classic piebald was previously thought to be the same recessive allele in the endothelin B receptor gene (Ednrb) according to the haplotype pattern, which is insufficient for this conclusion. In this study, we identified the same insertion of a retroposon-like element in intron 1 of the Ednrb gene in JF1 as in the classic piebald mutation by PCR. Further, we investigated whether the intestine shows neuronal intestinal malformations such as hypoganglionosis and immaturity of ganglion cells by histochemical staining. Though it has been assumed that the defect of neural crest-derived lineages is restricted to melanocytes in JF1, we found that the enteric innervation and neuronal density were impaired throughout the whole colon in JF1 mice.

Web of Science ® 被引用回数 : 4

リンク情報
DOI
https://doi.org/10.1292/jvms.11-0447
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/22067082
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000303137700021&DestApp=WOS_CPL
ID情報
  • DOI : 10.1292/jvms.11-0447
  • ISSN : 0916-7250
  • PubMed ID : 22067082
  • Web of Science ID : WOS:000303137700021

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