2012年3月
Anatomic Modifications in the Enteric Nervous System of JF1 Mice with the Classic Piebald Mutation
JOURNAL OF VETERINARY MEDICAL SCIENCE
- ,
- ,
- ,
- 巻
- 74
- 号
- 3
- 開始ページ
- 391
- 終了ページ
- 394
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1292/jvms.11-0447
- 出版者・発行元
- JAPAN SOC VET SCI
The Japanese Fancy Mouse 1 (JF1) has a characteristic coat color similar to a very old mutant, piebald. The mutation in JF1 and the classic piebald was previously thought to be the same recessive allele in the endothelin B receptor gene (Ednrb) according to the haplotype pattern, which is insufficient for this conclusion. In this study, we identified the same insertion of a retroposon-like element in intron 1 of the Ednrb gene in JF1 as in the classic piebald mutation by PCR. Further, we investigated whether the intestine shows neuronal intestinal malformations such as hypoganglionosis and immaturity of ganglion cells by histochemical staining. Though it has been assumed that the defect of neural crest-derived lineages is restricted to melanocytes in JF1, we found that the enteric innervation and neuronal density were impaired throughout the whole colon in JF1 mice.
- リンク情報
- ID情報
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- DOI : 10.1292/jvms.11-0447
- ISSN : 0916-7250
- PubMed ID : 22067082
- Web of Science ID : WOS:000303137700021