論文

査読有り 国際誌
2003年6月

Impairment of reward-related learning by cholinergic cell ablation in the striatum

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
  • Y Kitabatake
  • ,
  • T Hikida
  • ,
  • D Watanabe
  • ,
  • Pastan, I
  • ,
  • S Nakanishi

100
13
開始ページ
7965
終了ページ
7970
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1073/pnas.1032899100
出版者・発行元
NATL ACAD SCIENCES

The striatum in the basal ganglia-thalamocortical circuitry is a key neural substrate that is implicated in motor balance and procedural learning. The projection neurons in the striatum are dynamically modulated by nigrostriatal dopaminergic input and intrastriatal cholinergic input. The role of intrastriatal acetylcholine (ACh) in learning behaviors, however, remains to be fully clarified. In this investigation, we examine the involvement of intrastriatal ACh in different categories of learning by selectively ablating the striatal cholinergic neurons with use of immunotoxin-mediated cell targeting. We show that selective ablation of cholinergic neurons in the striatum impairs procedural learning in the tone-cued T-maze memory task. Spatial delayed alternation in the T-maze learning test is also impaired by cholinergic cell elimination. In contrast, the deficit in striatal ACh transmission has no effect on motor learning in the rota-rod test or spatial learning in the Morris water-maze test or on contextual- and tone-cued conditioning fear responses. We also report that cholinergic cell elimination adaptively upregulates nicotinic ACh receptors not only within the striatum but also in the cerebral cortex and substantia nigra. The present investigation indicates that cholinergic modulation in the local striatal circuit plays a pivotal role in regulation of neural circuitry involving reward-related procedural learning and working memory.

リンク情報
DOI
https://doi.org/10.1073/pnas.1032899100
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/12802017
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC164696
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000183845800099&DestApp=WOS_CPL
ID情報
  • DOI : 10.1073/pnas.1032899100
  • ISSN : 0027-8424
  • PubMed ID : 12802017
  • PubMed Central 記事ID : PMC164696
  • Web of Science ID : WOS:000183845800099

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