2011年9月
miR-124a is required for hippocampal axogenesis and retinal cone survival through Lhx2 suppression
NATURE NEUROSCIENCE
- 巻
- 14
- 号
- 9
- 開始ページ
- 1125
- 終了ページ
- U177
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/nn.2897
- 出版者・発行元
- NATURE PUBLISHING GROUP
MicroRNA-124a (miR-124a) is the most abundant microRNA expressed in the vertebrate CNS. Despite past investigations into the role of miR-124a, inconsistent results have left the in vivo function of miR-124a unclear. We examined the in vivo function of miR-124a by targeted disruption of Rncr3 (retinal non-coding RNA 3), the dominant source of miR-124a. Rncr3(-/-) mice exhibited abnormalities in the CNS, including small brain size, axonal mis-sprouting of dentate gyrus granule cells and retinal cone cell death. We found that Lhx2 is an in vivo target mRNA of miR-124a. We also observed that LHX2 downregulation by miR-124a is required for the prevention of apoptosis in the developing retina and proper axonal development of hippocampal neurons. These results suggest that miR-124a is essential for the maturation and survival of dentate gyrus neurons and retinal cones, as it represses Lhx2 translation.
- リンク情報
-
- DOI
- https://doi.org/10.1038/nn.2897
- J-GLOBAL
- https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201102214242009959
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/21857657
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000294284900012&DestApp=WOS_CPL
- ID情報
-
- DOI : 10.1038/nn.2897
- ISSN : 1097-6256
- J-Global ID : 201102214242009959
- PubMed ID : 21857657
- Web of Science ID : WOS:000294284900012