2016年11月
Preparation and antioxidant/pro-oxidant activities of 3-monosubstituted 5-hydroxyoxindole derivatives
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
- ,
- ,
- ,
- ,
- 巻
- 59
- 号
- 3
- 開始ページ
- 165
- 終了ページ
- 173
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.3164/jcbn.16-24
- 出版者・発行元
- JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION
Antioxidant treatments have been expected to be a novel therapeutics for various oxidative stress-mediated disorders. Our previous study revealed that 5-hydroxyoxindole and its 3-phenacyl3-hydroxy derivatives showed excellent antioxidant activities such as 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity and lipid-peroxidation inhibitory activity. However, the DPPH radical scavenging activity of the 3,3-disubstituted derivatives was lower than that of the original 5-hydroxyoxindole. In the present study, we synthesized novel 3-monosubstituted 5-hydroxyoxindole derivatives that exhibited stronger DPPH radical scavenging activities and lipid peroxidation-inhibitory activities than the 3,3disubstituted 5-hydroxyoxindoles. Moreover, the 3-monosubstituted 5-hydroxyoxindole derivatives showed neither an iron mediated pro-oxidant effect nor a remarkable cytotoxicity against HL-60 cell lines except some of the highly lipophilic compounds. These results indicate that 3-monosubstituted 5-hydroxyoxindoles can be used as a promising antioxidant scaffold for drug discovery.
- リンク情報
- ID情報
-
- DOI : 10.3164/jcbn.16-24
- ISSN : 0912-0009
- eISSN : 1880-5086
- SCOPUS ID : 84994097049
- Web of Science ID : WOS:000390084300003