論文

査読有り
2016年11月

Preparation and antioxidant/pro-oxidant activities of 3-monosubstituted 5-hydroxyoxindole derivatives

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
  • Daisuke Yasuda
  • ,
  • Kyoko Takahashi
  • ,
  • Tomoyuki Ohe
  • ,
  • Shigeo Nakamura
  • ,
  • Tadahiko Mashino

59
3
開始ページ
165
終了ページ
173
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3164/jcbn.16-24
出版者・発行元
JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION

Antioxidant treatments have been expected to be a novel therapeutics for various oxidative stress-mediated disorders. Our previous study revealed that 5-hydroxyoxindole and its 3-phenacyl3-hydroxy derivatives showed excellent antioxidant activities such as 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity and lipid-peroxidation inhibitory activity. However, the DPPH radical scavenging activity of the 3,3-disubstituted derivatives was lower than that of the original 5-hydroxyoxindole. In the present study, we synthesized novel 3-monosubstituted 5-hydroxyoxindole derivatives that exhibited stronger DPPH radical scavenging activities and lipid peroxidation-inhibitory activities than the 3,3disubstituted 5-hydroxyoxindoles. Moreover, the 3-monosubstituted 5-hydroxyoxindole derivatives showed neither an iron mediated pro-oxidant effect nor a remarkable cytotoxicity against HL-60 cell lines except some of the highly lipophilic compounds. These results indicate that 3-monosubstituted 5-hydroxyoxindoles can be used as a promising antioxidant scaffold for drug discovery.

リンク情報
DOI
https://doi.org/10.3164/jcbn.16-24
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000390084300003&DestApp=WOS_CPL
ID情報
  • DOI : 10.3164/jcbn.16-24
  • ISSN : 0912-0009
  • eISSN : 1880-5086
  • SCOPUS ID : 84994097049
  • Web of Science ID : WOS:000390084300003

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