論文

査読有り
2011年10月

Furan fatty acid as an anti-inflammatory component from the green-lipped mussel Perna canaliculus

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
  • Toshiyuki Wakimoto
  • Hikaru Kondo
  • Hirohiko Nii
  • Kaori Kimura
  • Yoko Egami
  • Yusuke Oka
  • Masae Yoshida
  • Eri Kida
  • Yiping Ye
  • Saeko Akahoshi
  • Tomohiro Asakaw
  • Koichi Matsumura
  • Hitoshi Ishida
  • Haruo Nukaya
  • Kuniro Tsuji
  • Toshiyuki Kan
  • Ikuro Abe
  • 全て表示

108
42
開始ページ
17533
終了ページ
17537
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1073/pnas.1110577108
出版者・発行元
NATL ACAD SCIENCES

A lipid extract of Perna canaliculus (New Zealand green-lipped mussel) has reportedly displayed anti-inflammatory effects in animal models and in human controlled studies. However, the anti-inflammatory lipid components have not been investigated in detail due to the instability of the lipid extract, which has made the identification of the distinct active components a formidable task. Considering the instability of the active component, we carefully fractionated a lipid extract of Perna canaliculus (Lyprinol) and detected furan fatty acids (F-acids). These naturally but rarely detected fatty acids show potent radical-scavenging ability and are essential constituents of plants and algae. Based on these data, it has been proposed that F-acids could be potential antioxidants, which may contribute to the protective properties of fish and fish oil diets against chronic inflammatory diseases. However, to date, in vivo data to support the hypothesis have not been obtained, presumably due to the limited availability of F-acids. To confirm the in vivo anti-inflammatory effect of F-acids in comparison with that of eicosapentaenoic acid (EPA), we developed a semisynthetic preparation and examined its anti-inflammatory activity in a rat model of adjuvant-induced arthritis. Indeed, the F-acid ethyl ester exhibited more potent anti-inflammatory activity than that of the EPA ethyl ester. We report on the in vivo activity of F-acids, confirming that the lipid extract of the green-lipped mussel includes an unstable fatty acid that is more effective than EPA.

リンク情報
DOI
https://doi.org/10.1073/pnas.1110577108
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000295975300061&DestApp=WOS_CPL
ID情報
  • DOI : 10.1073/pnas.1110577108
  • ISSN : 0027-8424
  • Web of Science ID : WOS:000295975300061

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