2012年
Porphyrins from a metagenomic library of the marine sponge Discodermia calyx
MOLECULAR BIOSYSTEMS
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- 巻
- 8
- 号
- 9
- 開始ページ
- 2334
- 終了ページ
- 2338
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1039/c2mb25169h
- 出版者・発行元
- ROYAL SOC CHEMISTRY
Marine sponges harbouring uncultured symbiotic bacteria are important sources of biologically active compounds. Since they would be interesting resources to explore unknown functional genes by means of a metagenomic approach, we constructed a metagenomic library of the Japanese marine sponge Discodermia calyx. The functional screening afforded the two clones producing porphyrins as red pigments. The isolation and structural elucidation of the red pigments revealed that the major red pigment was Zn-coproporphyrin III. The sequence data of the clones identified genes encoding glutamyl-tRNA reductase along with other ORFs related to porphyrin biosynthesis.
- リンク情報
- ID情報
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- DOI : 10.1039/c2mb25169h
- ISSN : 1742-206X
- Web of Science ID : WOS:000307014300011