2012年2月
Calyxamides A and B, Cytotoxic Cyclic Peptides from the Marine Sponge Discodermia calyx
JOURNAL OF NATURAL PRODUCTS
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- 巻
- 75
- 号
- 2
- 開始ページ
- 290
- 終了ページ
- 294
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1021/np2009187
- 出版者・発行元
- AMER CHEMICAL SOC
Cyclic peptides containing 5-hydroxytryptophan and thiazole moieties were isolated from the marine sponge Discodermia calyx collected near Shikine-jima Island, Japan. The structures of calyxamides A (1) and B (2), including the absolute configurations of all amino acids, were elucidated by spectroscopic analyses and degradation experiments. The structures are similar to keramamides F and G, previously isolated from Theonella sp. The analysis of the 16S rDNA sequences obtained from the metagenomic DNA of D. calyx revealed the presence of Canclidatus Entotheonella sp., an unculturable fi-proteobacterium inhabiting the Theonella genus and implicated in the biosynthesis of bioactive peptides.
- リンク情報
- ID情報
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- DOI : 10.1021/np2009187
- ISSN : 0163-3864
- Web of Science ID : WOS:000300601500028