論文

査読有り
2012年2月

Calyxamides A and B, Cytotoxic Cyclic Peptides from the Marine Sponge Discodermia calyx

JOURNAL OF NATURAL PRODUCTS
  • Miki Kimura
  • ,
  • Toshiyuki Wakimoto
  • ,
  • Yoko Egami
  • ,
  • Karen Co Tan
  • ,
  • Yuji Ise
  • ,
  • Ikuro Abe

75
2
開始ページ
290
終了ページ
294
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1021/np2009187
出版者・発行元
AMER CHEMICAL SOC

Cyclic peptides containing 5-hydroxytryptophan and thiazole moieties were isolated from the marine sponge Discodermia calyx collected near Shikine-jima Island, Japan. The structures of calyxamides A (1) and B (2), including the absolute configurations of all amino acids, were elucidated by spectroscopic analyses and degradation experiments. The structures are similar to keramamides F and G, previously isolated from Theonella sp. The analysis of the 16S rDNA sequences obtained from the metagenomic DNA of D. calyx revealed the presence of Canclidatus Entotheonella sp., an unculturable fi-proteobacterium inhabiting the Theonella genus and implicated in the biosynthesis of bioactive peptides.

リンク情報
DOI
https://doi.org/10.1021/np2009187
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000300601500028&DestApp=WOS_CPL
ID情報
  • DOI : 10.1021/np2009187
  • ISSN : 0163-3864
  • Web of Science ID : WOS:000300601500028

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