論文

査読有り
2014年11月

Phosphocalyculin C as a pyrophosphate protoxin of calyculin C in the marine sponge Discodermia calyx

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
  • Yoko Egami
  • ,
  • Toshiyuki Wakimoto
  • ,
  • Ikuro Abe

24
22
開始ページ
5150
終了ページ
5153
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.bmcl.2014.10.002
出版者・発行元
PERGAMON-ELSEVIER SCIENCE LTD

Calyculin C, a minor derivative of the calyculins, has an additional methyl group on C32 of calyculin A. A recent biosynthetic study of calyculins revealed that an end product of calyculin biosynthesis is the pyrophosphate form, phosphocalyculin A. However, the pyrophosphate counterpart derived from calyculin C had not been reported. We isolated phosphocalyculin C as a minor pyrophosphate derivative, by a detailed investigation of an extract from the sponge Discodermia calyx. The treatment of phosphocalyculin C with the D. calyx cell-free extract significantly enhanced its cytotoxicity, providing molecular evidence for its role as the protoxin of calyculin C. (C) 2014 Elsevier Ltd. All rights reserved.

リンク情報
DOI
https://doi.org/10.1016/j.bmcl.2014.10.002
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000343901400002&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.bmcl.2014.10.002
  • ISSN : 0960-894X
  • eISSN : 1464-3405
  • Web of Science ID : WOS:000343901400002

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