2014年11月
Phosphocalyculin C as a pyrophosphate protoxin of calyculin C in the marine sponge Discodermia calyx
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- ,
- ,
- 巻
- 24
- 号
- 22
- 開始ページ
- 5150
- 終了ページ
- 5153
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.bmcl.2014.10.002
- 出版者・発行元
- PERGAMON-ELSEVIER SCIENCE LTD
Calyculin C, a minor derivative of the calyculins, has an additional methyl group on C32 of calyculin A. A recent biosynthetic study of calyculins revealed that an end product of calyculin biosynthesis is the pyrophosphate form, phosphocalyculin A. However, the pyrophosphate counterpart derived from calyculin C had not been reported. We isolated phosphocalyculin C as a minor pyrophosphate derivative, by a detailed investigation of an extract from the sponge Discodermia calyx. The treatment of phosphocalyculin C with the D. calyx cell-free extract significantly enhanced its cytotoxicity, providing molecular evidence for its role as the protoxin of calyculin C. (C) 2014 Elsevier Ltd. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.bmcl.2014.10.002
- ISSN : 0960-894X
- eISSN : 1464-3405
- Web of Science ID : WOS:000343901400002