Apr, 2017 - Mar, 2020
New bone augmentation technique through bone metabolism regulation using IGFBP-3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
- Grant number
- 17K17161
- Japan Grant Number (JGN)
- JP17K17161
- Authorship
- Principal investigator
- Grant amount
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- (Total)
- 4,030,000 Japanese Yen
- (Direct funding)
- 3,100,000 Japanese Yen
- (Indirect funding)
- 930,000 Japanese Yen
- Grant type
- Competitive
In this study, we focused on the possibility that insulin-like growth factor binding protein-3 (IGFBP-3) has a new IGF-independent function in bone tissue, and IGFBP-3 may play a part in the regulation of bone metabolism. The aim of this project was to analyze the effect of IGFBP-3 on the differentiation of mesenchymal stem cells into osteoblasts. The addition of IGFBP-3 in the osteoblast culture system under certain conditions has decreased the gene expression level of the osteoblast differentiation marker, lowered ALP activity, and suppressed calcification. Furthermore, it was suggested that IGFBP-3 might suppress osteoblast differentiation and maturation by inhibiting BMP-2 signaling.
- Link information
- ID information
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- Grant number : 17K17161
- Japan Grant Number (JGN) : JP17K17161