2013年7月
Accumulation of invariant NKT cells into inflamed skin in a novel murine model of nickel allergy
Cellular Immunology
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- 巻
- 284
- 号
- 1-2
- 開始ページ
- 163
- 終了ページ
- 171
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.cellimm.2013.07.010
- 出版者・発行元
- Elsevier BV
Nickel (Ni) can cause delayed-type hypersensitivity reactions, which are thought to be mediated by the accumulation of T cells into inflamed skin. Accumulated T cells at the developmental stages in metal allergy are poorly characterized because a suitable animal model has not been established. To investigate the accumulated T cells in allergic inflamed skin, we generated a novel murine model of Ni-induced allergy. The murine model of Ni allergy was induced by two sensitizations of Ni plus lipopolysaccharide solution into the groin followed by three challenges with Ni solution into the footpad. Here we show that a specific TCR repertoire bearing Vα14Jα18, called natural killer (NK) T cells, was expanded monoclonally in BALB/c or C57BL/6 mice. Accumulation of NKT cells was characterized as CD4+ or CD4-CD8- T cells. These results suggested that NKT cells are major pathogenic T cells at the elicitation phase of Ni allergy. © 2013 Elsevier Inc.
- リンク情報
- ID情報
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- DOI : 10.1016/j.cellimm.2013.07.010
- ISSN : 0008-8749
- ISSN : 1090-2163
- PubMed ID : 23978680
- SCOPUS ID : 84882977336