Eiichi Okamura

Profile Information

Degree: Ph.D.(University of Tsukuba)

J-GLOBAL ID: 201801006707249150
researchmap Member ID: B000338195

External link

Research Areas

Life sciences / Developmental biology /

Awards

Mar, 2013

生命環境科学研究科長賞, 筑波大学大学院生命環境科学研究科

岡村永一

Papers

Essential Roles of Exocyst Complex Component 3-like 2 on Cardiovascular Development in Mice.

Chisato Watanabe, Hirotoshi Shibuya, Yusuke Ichiyama, Eiichi Okamura, Setsuko Tsukiyama-Fujii, Tomoyuki Tsukiyama, Shoma Matsumoto, Jun Matsushita, Takuya Azami, Yoshiaki Kubota, Masahito Ohji, Fumihiro Sugiyama, Satoru Takahashi, Seiya Mizuno, Masaru Tamura, Ken-Ichi Mizutani, Masatsugu Ema

Life (Basel, Switzerland), 12(11), Oct 28, 2022
Recapitulation of gametic DNA methylation and its post-fertilization maintenance with reassembled DNA elements at the mouse Igf2/H19 locus.

Hitomi Matsuzaki, Daichi Kuramochi, Eiichi Okamura, Katsuhiko Hirakawa, Aki Ushiki, Keiji Tanimoto

Epigenetics & chromatin, 13(1) 2-2, Jan 14, 2020 Peer-reviewed
Generation of Transgenic Cynomolgus Monkeys Overexpressing the Gene for Amyloid-β Precursor Protein.

Yasunari Seita, Toshifumi Morimura, Naoki Watanabe, Chizuru Iwatani, Hideaki Tsuchiya, Shinichiro Nakamura, Toshiharu Suzuki, Daijiro Yanagisawa, Tomoyuki Tsukiyama, Masataka Nakaya, Eiichi Okamura, Masanaga Muto, Masatsugu Ema, Masaki Nishimura, Ikuo Tooyama

Journal of Alzheimer's disease : JAD, 75(1) 45-60, 2020 Peer-reviewed
Esrrb function is required for proper primordial germ cell development in presomite stage mouse embryos.

Okamura E, Tam OH, Posfai E, Li L, Cockburn K, Lee CQE, Garner J, Rossant J

Developmental biology, 455(2) 382-392, Nov, 2019 Peer-reviewed
Transvection-like interchromosomal interaction is not observed at the transcriptional level when tested in the Rosa26 locus in mouse.

Tanimoto K, Matsuzaki H, Okamura E, Ushiki A, Fukamizu A, Engel JD

PloS one, 14(2) e0203099, 2019 Peer-reviewed
Synthetic DNA fragments bearing ICR cis elements become differentially methylated and recapitulate genomic imprinting in transgenic mice.

Hitomi Matsuzaki, Eiichi Okamura, Daichi Kuramochi, Aki Ushiki, Katsuhiko Hirakawa, Akiyoshi Fukamizu, Keiji Tanimoto

Epigenetics & Chromatin, Vol.11(No.1), Jun, 2018 Peer-reviewed
De novo DNA methylation through the 5 '-segment of the H19 ICR maintains its imprint during early embryogenesis

Hitomi Matsuzaki, Eiichi Okamura, Takuya Takahashi, Aki Ushiki, Toshinobu Nakamura, Toru Nakano, Kenichiro Hata, Akiyoshi Fukamizu, Keiji Tanimoto

DEVELOPMENT, 142(22) 3833-3844, Nov, 2015 Peer-reviewed
Sox-Oct motifs contribute to maintenance of the unmethylated H19 ICR in YAC transgenic mice

Ryuuta Sakaguchi, Eiichi Okamura, Hitomi Matsuzaki, Akiyoshi Fukamizu, Keiji Tanimoto

Human Molecular Genetics, 22(22) 4627-4637, Nov, 2013 Peer-reviewed
The Chicken HS4 Insulator Element Does Not Protect the H19 ICR from Differential DNA Methylation in Yeast Artificial Chromosome Transgenic Mouse

Eiichi Okamura, Hitomi Matsuzaki, Akiyoshi Fukamizu, Keiji Tanimoto

PLOS ONE, 8(9) e73925-e73925, Sep, 2013 Peer-reviewed
The H19 Imprinting Control Region Mediates Preimplantation Imprinted Methylation of Nearby Sequences in Yeast Artificial Chromosome Transgenic Mice

Eiichi Okamura, Hitomi Matsuzaki, Ryuuta Sakaguchi, Takuya Takahashi, Akiyoshi Fukamizu, Keiji Tanimoto

MOLECULAR AND CELLULAR BIOLOGY, 33(4) 858-871, Feb, 2013 Peer-reviewed
Sequences in the H19 ICR that are transcribed as small RNA in oocytes are dispensable for methylation imprinting in YAC transgenic mice

Takuya Takahashi, Hitomi Matsuzaki, Shin-ichi Tomizawa, Eiichi Okamura, Tomoko Ichiyanagi, Akiyoshi Fukamizu, Hiroyuki Sasaki, Keiji Tanimoto

GENE, 508(1) 26-34, Oct, 2012 Peer-reviewed
DNase I Hypersensitivity and epsilon-Globin Transcriptional Enhancement Are Separable in Locus Control Region (LCR) HS1 Mutant Human beta-Globin YAC Transgenic Mice

Motoshi Shimotsuma, Eiichi Okamura, Hitomi Matsuzaki, Akiyoshi Fukamizu, Keiji Tanimoto

JOURNAL OF BIOLOGICAL CHEMISTRY, 285(19) 14495-14503, May, 2010 Peer-reviewed
CTCF binding is not the epigenetic mark that establishes post-fertilization methylation imprinting in the transgenic H19 ICR

Hitomi Matsuzaki, Eiichi Okamura, Akiyoshi Fukamizu, Keiji Tanimoto

HUMAN MOLECULAR GENETICS, 19(7) 1190-1198, Apr, 2010 Peer-reviewed
All of the human beta-type globin genes compete for LCR enhancer activity in embryonic erythroid cells of yeast artificial chromosome transgenic mice

Eiichi Okamura, Hitomi Matsuzaki, Andrew D. Campbell, James Douglas Engel, Akiyoshi Fukamizu, Keiji Tanimoto

FASEB JOURNAL, 23(12) 4335-4343, Dec, 2009 Peer-reviewed
A Randomly Integrated Transgenic H19 Imprinting Control Region Acquires Methylation Imprinting Independently of Its Establishment in Germ Cells

Hitomi Matsuzaki, Eiichi Okamura, Motoshi Shimotsuma, Akiyoshi Fukamizu, Keiji Tanimoto

MOLECULAR AND CELLULAR BIOLOGY, 29(17) 4595-4603, Sep, 2009 Peer-reviewed

Misc.

遺伝子改変技術の新展開非ヒト霊長類の1種であるカニクイザルにおける遺伝子改変技術の進展

依馬正次, 岡村永一

日本生化学会大会プログラム・講演要旨集, 94回 [1S08e-01], Nov, 2021
非ヒト霊長類の1種であるカニクイザル胎盤に由来する栄養膜幹細胞の樹立

岡村永一, 武藤真長, 松本翔馬, Jargalsaikhan Bat-Erdene, 依馬正次

日本生化学会大会プログラム・講演要旨集, 94回 [2T14a-616)], Nov, 2021
非ヒト霊長類の1種であるカニクイザル胎盤に由来する栄養膜幹細胞の樹立

岡村永一, 武藤真長, 松本翔馬, Jargalsaikhan Bat-Erdene, 依馬正次

日本生化学会大会プログラム・講演要旨集, 94回 [P-12)], Nov, 2021
迅速な心筋特異的ノックアウトマウスシステムの開発

依馬朋香, 村田知弥, 岡村永一, 三上夏輝, 松本翔馬, 水野聖哉, 依馬正次, 杉山文博

日本生化学会大会プログラム・講演要旨集, 94回 [P-1008], Nov, 2021
Human disease modeling with genetically-modified cynomologus monkey, a nonhuman primate

岡村永一, 依馬正次

Bio Clinica, 36(5), 2021
研究者の最新動向非ヒト霊長類の1種であるカニクイザルを用いたヒト疾患モデリング

依馬正次, 岡村永一

Precision Medicine, 3(6) 568-570, Jun, 2020
異なる培養条件で樹立したカニクイザル栄養膜幹細胞の比較解析

松本翔馬, 武藤真長, 岡村永一, JARGALSAIKHAN Bat-Erdene, 田中智, 依馬正次

日本分子生物学会年会プログラム・要旨集(Web), 43rd, 2020

Books and Other Publications

カニクイザルにおける遺伝子改変技術の現状と創薬研究への展開

岡村永一、依馬正次 (Role: Joint author)

オベリスクハムリー株式会社, Jan, 2022
遺伝子改変カニクイザルを用いたヒト疾患モデリング

岡村永一, 依馬正次 (Role: Joint author)

BIO Clinica バイオクリニカ北陸館, May, 2021
非ヒト霊長類の１種であるカニクイザルを用いたヒト疾患モデリング

依馬正次, 岡村永一 (Role: Joint author)

Precision Medicine 北陸館, Jun, 2020

Presentations

Optimization of the production of transgenic animals using PiggyBAC transposon system

Nov 11, 2022
Development of cardiomyocyte-specific hyper-speed knockout system by using in vivo genome editing

Tomoka Ema, Kazuya Murata, Eiichi Okamura, Natsuki Mikami, Shoma Matsumoto, Seiya Mizuno, Masatsugu Ema, Fumihiro Sugiyama
Establishment of trophoblast stem cell line from cynomolgus monkey placenta

The 94th Annual Meeting of the Japanese Biochemical Society, Nov 4, 2021
迅速な心筋特異的ノックアウトマウスシステムの開発

依馬朋香, 村田知弥, 岡村永一, 三上夏輝, 松本翔馬, 水野聖哉, 依馬正次, 杉山文博

第94回日本生化学会大会
Comparative analysis of cynomolgus monkey trophoblast stem cells established under different condition

Shoma Matsumoto, Masanaga Muto, Eiichi Okamura, Bat-Erdene Jargalsaikhan, Satoshi Tanaka

The 43rd Annual Meeting of the Molecular Biology Society of Japan, Dec 2, 2020
Esrrb in extraembryonic ectoderm regulates primordial germ cell development through Bmp4 gene activation

Eiichi Okamura, Posfai Eszter, Tam Oliver, Li Lingyu, Garner Jodi, Rossant Janet

ConBio2017, Dec 7, 2017
Esrrb in the extraembryonic ectoderm regulates primordial germ cell development in the mouse embryo

Eiichi OKamura, Eszter Posfai, Oliver Tam, Lingyu Li, Jodi Garner, Janet Rossant

The International Research Symposium on Regulation of Germ Cell Development in vivo and in vitro, Jul 26, 2017
マウス初期胚発生期における核内受容体型転写因子 Esrrb の機能解析

Eiichi Okamura, Posfai Eszter, Li Lingyu, Garner Jodi, Tam Oliver, Rossant Janet

第1回次世代生命科学の研究会, Aug 12, 2016
Esrrb and Cdx2 co-operatively regulate gene transcription in trophoblast stem cells

Eiichi Okamura, Li Lingyu, Garner Jodi, Tam Oliver, Rossant Janet

BMB2015, Dec 3, 2015
De novo DNA methylation mediated by 5’ portion of the H19 ICR is essential for maintaining its methylation imprintduring early embryogenesis in mice

Keiji Tanimoto, Hitomi Matsuzaki, Eiichi Okamura, Aki Ushiki, Takuya Takahashi

Mouse Molecular Genetics, Sep 16, 2015
A role for postfertilization, allele-specific DNA methylation activity in maintaining the imprinted H19 ICR methylation

Hitomi Matsuzaki, Eiichi Okamura, Aki Ushiki, Takuya Takahashi, Keiji Tanimoto

Keystone Symposia (DNA methylation), Mar 29, 2015
Igf2/H19 刷り込み遺伝子座における受精後アリル特異的 DNA メチル化活性の解析

松﨑仁美, 岡村永一, 牛木亜季, 高橋拓也, 谷本啓司

第37回日本分子生物学会年会, Nov 25, 2014
Differential transcriptional regulation by Esrrb between in ES and TS cells

Eiichi Okamura, Lingyu Li, Jodi Garner, Oliver Tam, Janet Rossant

Oct 27, 2014
Sox-Oct motifs maintain the unmathylated state of the H19 ICR in YAC transgenic mice

Hitomi Matsuzaki, Ryuuichi Sakaguchi, Eiichi Okamura, Keiji Tanimoto

Keystone Symposia (Epigenetic Programming and Inheritance), Apr 6, 2014
Allele-specific, post-fertilization DNA methylation activity is essential for patching up imprinted H19-ICR methylation status

Hitomi Matsuzaki, Eiichi Okamura, Aki Ushiki, Takuya Takahashi, Keiji Tanimoto

Keystone Symposia (Epigenetic Programming and Inheritance), Apr 6, 2014
The H19 ICR mediates pre-implantation imprinted methylation of nearby sequences in YAC transgenic mice

Eiichi OKamura, Hitomi Matsuzaki, Keiji Tanimoto

CDB Symposium 2013 - The Making of a Vertebrate -, Mar 4, 2013
In vivo analysis of the Oct motif function in imprinted methylation of the H19 ICR

Dec 14, 2012
Small RNA sequences in the H19-ICR is dispensable for its methylation imprinting in yeast artificial chromosome transgenic mice

Takuya Takahashi, Hitomi Matsuzaki, Eiichi Okamura, Keiji Tanimoto

Keystone Symposia (Epigenomics), Jan 17, 2012
The H19-ICR bears activities that can introduce imprinted DNA methylation into adjacent, heterologous DNA sequences in YAC transgenic mice

Eiichi Okamura, Ryuuta Sakaguchi, Hitomi Matsuzaki, Keiji Tanimoto

Keystone Symposia (Epigenomics), Jan 17, 2012
Functional analysis of Sox-Oct motif in the establishment of differential methylation at the transgenic H19 ICR

Dec 13, 2011

Professional Memberships

Jun, 2021 - Present

日本生化学会
May, 2019 - Present

日本ゲノム編集学会
Feb, 2016 - Present

JAPANESE SOCIETY OF DEVELOPMENTAL BIOLOGISTS
Apr, 2009 - Present

THE JAPANESE SOCIETY OF EPIGENETICS
Jun, 2008 - Present

THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

Research Projects

新規カニクイザル発生工学技術を用いた栄養膜特異的ノックアウト法の開発

科学研究費助成事業基盤研究(C), 日本学術振興会, Apr, 2021 - Mar, 2024

岡村永一, 水野直彬
トランスポゾン技術を用いた効率的な疾患モデルカニクイザル作製法の開発

2021年度助成金, 公益財団法人ハーモニック財団, Apr, 2021 - Mar, 2023
トランスポゾンベクターを用いたカニクイザルにおける新規遺伝子改変技術の開発とヒト疾患モデルの作製

第1回NHP-A研究助成（2020年度）, 予防衛生協会, Apr, 2021 - Mar, 2022
Y染色体CRISPRイメージング技術の確立と哺乳動物の雌雄産み分け

科学研究費助成事業若手研究, 日本学術振興会, Apr, 2019 - Mar, 2021

岡村永一
性ホルモン依存性精神疾患を規定するエピゲノムコードの解明

Grants-in-Aid for Scientific Research, Apr, 2017 - Mar, 2020

松本高広
新規Y染色体改変技術の開発と雄性特異的ゲノム機能解析

医学系研究奨励, 公益財団法人武田科学振興財団, Aug, 2015 - Mar, 2018

岡村永一
Y染色体イメージング法による家畜哺乳動物の雌雄産み分け技術の開発

2016年度研究助成金, 一般財団法人旗影会, Apr, 2016 - Mar, 2017

岡村永一
Identification of upstream signaling pathway responsible for primordial germ cell specification

Grants-in-Aid for Scientific Research, Aug, 2015 - Mar, 2017

OKAMURA Eiichi
精子形成におけるY染色体遺伝子の機能解析

医学・歯学研究奨励助成, 一般財団法人厚仁会, Jul, 2015 - Jun, 2016

岡村永一
酵母人工染色体導入マウスを用いたアリル特異的エピジェネティック・マークの探索

科学研究費補助金特別研究員奨励費, Apr, 2011 - Mar, 2012

岡村永一

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