2017年12月
Ability of higenamine and related compounds to enhance glucose uptake in L6 cells
BIOORGANIC & MEDICINAL CHEMISTRY
- ,
- ,
- 巻
- 25
- 号
- 24
- 開始ページ
- 6412
- 終了ページ
- 6416
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.bmc.2017.10.011
- 出版者・発行元
- PERGAMON-ELSEVIER SCIENCE LTD
beta 2-Adrenergic receptor (beta 2AR) agonists are employed as bronchodilators to treat pulmonary disorders, but are attracting attention for their modulation of glucose handling and energy expenditure. Higenamine is a tetrahydroisoquinoline present in several plant species and has beta 2AR agonist activity, but the involvement of each functional groups in beta 2AR agonist activity and its effectiveness compared with endogenous catecholamines (dopamine, epinephrine, and norepinephrine) has rarely been studied. Glucose uptake of muscle cells are known to be induced through beta 2AR activation. Here, the ability to enhance glucose uptake of higenamine was compared with that of several methylated derivatives of higenamine or endogenous catecholamines. We found that: (i) the functional groups of higenamine except for the 40-hydroxy group are required to enhance glucose uptake; (ii) higenamine shows a comparable ability to enhance glucose uptake with that of epinephrine and norepinephrine; (iii) the S-isomer shows a greater ability to enhance glucose uptake compared with that of the R-isomer. (C) 2017 Elsevier Ltd. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.bmc.2017.10.011
- ISSN : 0968-0896
- eISSN : 1464-3391
- ORCIDのPut Code : 37639435
- Web of Science ID : WOS:000415984900016