論文

査読有り 国際誌
2018年6月29日

Numb has distinct function in lung adenocarcinoma and squamous cell carcinoma.

Oncotarget
  • Hajime Kikuchi
  • ,
  • Jun Sakakibara-Konishi
  • ,
  • Megumi Furuta
  • ,
  • Eiki Kikuchi
  • ,
  • Junko Kikuchi
  • ,
  • Satoshi Oizumi
  • ,
  • Yasuhiro Hida
  • ,
  • Kichizo Kaga
  • ,
  • Ichiro Kinoshita
  • ,
  • Hirotoshi Dosaka-Akita
  • ,
  • Masaharu Nishimura

9
50
開始ページ
29379
終了ページ
29391
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.18632/oncotarget.25585

Some reports suggest that Numb is a potential tumor suppressor. However, its role in non-small cell lung cancer remains unclear. Non-small cell lung cancer comprises two major histological subtypes, adenocarcinoma and squamous cell carcinoma. To investigate the role of Numb in tumorigenesis of lung adenocarcinoma and squamous cell carcinoma, we firstly performed loss-of-function and gain-of-function assays. Moreover, Numb expression was investigated in surgically resected lung adenocarcinoma and squamous cell carcinoma tissues by immunohistochemistry and correlations with prognosis were analyzed. Numb suppressed the proliferation, migration, and invasion of adenocarcinoma cells and inhibited Notch signaling and epithelial-mesenchymal transition in vitro. Numb overexpression also inhibited subcutaneous adenocarcinoma tumor growth. In contrast, Numb promoted the proliferation, migration, and invasion of squamous cell carcinoma cells, but did not induce any consistent changes in Notch signaling. High Numb expression was associated with favorable prognosis in patients with lung adenocarcinoma, but not in those with squamous cell carcinoma. Collectively, our data demonstrate that Numb plays distinct roles in lung adenocarcinoma and squamous cell carcinoma. In lung adenocarcinoma, Numb impairs tumor growth and inhibits the Notch pathway and epithelial-mesenchymal transition, whereas in lung squamous cell carcinoma it may promote proliferation.

リンク情報
DOI
https://doi.org/10.18632/oncotarget.25585
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30034624
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047666

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