論文

査読有り 国際誌
2019年10月

Hepatic Campylobacter jejuni infection in patients with Castleman-Kojima disease (idiopathic multicentric Castleman disease with thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly (TAFRO) syndrome).

Pathology international
  • Chihiro Kageyama
  • ,
  • Takuro Igawa
  • ,
  • Yuka Gion
  • ,
  • Noriko Iwaki
  • ,
  • Tetsuya Tabata
  • ,
  • Takehiro Tanaka
  • ,
  • Eisei Kondo
  • ,
  • Hajime Sakai
  • ,
  • Koichi Tsuneyama
  • ,
  • Kazuhiro Nomoto
  • ,
  • Hiroko Noguchi
  • ,
  • Tadashi Yoshino
  • ,
  • Kenji Yokota
  • ,
  • Yasuharu Sato

69
10
開始ページ
572
終了ページ
579
記述言語
英語
掲載種別
DOI
10.1111/pin.12856

Castleman-Kojima disease, also known as idiopathic multicentric Castleman disease with TAFRO syndrome (iMCD-TAFRO), is a recently recognized systemic inflammatory disorder with a characteristic series of clinical symptoms, including thrombocytopenia (T), anasarca (A), fever (F), reticulin fibrosis (R), and organomegaly (O). Patients with iMCD-TAFRO often develop severe abdominal pain, elevated alkaline phosphatase levels, and systemic inflammation, but the etiological factors are unknown. To investigate the potential role of bacterial infection in the pathogenesis of iMCD-TAFRO, we performed polymerase chain reaction (PCR) for the bacterial 16S rRNA gene with DNA extracted from liver specimens of three patients with iMCD-TAFRO, four patients with amyotrophic lateral sclerosis, and seven patients with inflammatory conditions. Sequencing of the PCR product showed 99% DNA sequence identity with Campylobacter jejuni in all three patients with iMCD-TAFRO and in two patients with inflammatory conditions. Immunohistochemical and electron microscopy analyses could not identify C. jejuni in patients with iMCD-TAFRO. The findings indicated that C. jejuni infection is not the pathological cause of iMCD-TAFRO; however, this ubiquitous bacterium may play a role in uncontrolled systemic hypercytokinemia, possibly through the development of cross-reactive autoantibodies.


リンク情報
DOI
https://doi.org/10.1111/pin.12856
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31631463
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000491481800002&DestApp=WOS_CPL

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