論文

査読有り
2017年

The Clinical and Hormonal Characteristics of Primary Adrenal Lymphomas: The Necessity of Early Detection of Adrenal Insufficiency

INTERNAL MEDICINE
  • Ko Harada
  • ,
  • Kosuke Kimura
  • ,
  • Masaya Iwamuro
  • ,
  • Tomohiro Terasaka
  • ,
  • Yoshihisa Hanayama
  • ,
  • Eisei Kondo
  • ,
  • Eiko Hayashi
  • ,
  • Tadashi Yoshino
  • ,
  • Fumio Otsuka

56
17
開始ページ
2261
終了ページ
2269
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.2169/internalmedicine.8216-16
出版者・発行元
JAPAN SOC INTERNAL MEDICINE

Objective To analyze the clinical and endocrine characteristics of patients with primary adrenal lymphoma.
Patients We retrospectively reviewed the cases of five patients with primary adrenal lymphoma who were treated in our hospital between April 2004 and March 2015. We investigated the characteristics of the clinical and pathological findings, treatment, prognosis and complications of adrenal insufficiency.
Results Adrenal insufficiency, which was confirmed by the laboratory data at the initial presentation, was observed in two cases. One case was complicated by relative adrenal insufficiency during a course of chemotherapy. The plasma adrenaline and urinary adrenaline levels were decreased in four cases and three cases, respectively. Diffusion MRI was radiologically diagnostic. In all of the cases, the patients were pathologically diagnosed with diffuse large-B cell lymphoma and were treated with rituximab and CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone)-like chemotherapy. Two patients received central nervous system prophylaxis with high-dose methotrexate. Four of the patients survived and one patient died during the follow-up period.
Conclusion The early detection of adrenal insufficiency and the administration of an appropriate dose of hydrocortisone are necessary during the course of chemotherapy as well as at the initial manifestation. The exclusion of adrenal dysfunction prior to invasive diagnostic procedures, such as CT-guided needle biopsy, is also critical.

Web of Science ® 被引用回数 : 2

リンク情報
DOI
https://doi.org/10.2169/internalmedicine.8216-16
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000411760900003&DestApp=WOS_CPL
URL
http://www.scopus.com/inward/record.url?eid=2-s2.0-85028677252&partnerID=MN8TOARS
URL
http://orcid.org/0000-0003-0995-9405

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