論文

査読有り
2016年6月

Increased Serum KL-6 Levels Induced by Pulmonary Mycobacterium Avium Complex Infection in a Patient with RA-associated Lung Disease

ACTA MEDICA OKAYAMA
  • Koichi Waseda
  • ,
  • Kazuki Ocho
  • ,
  • Kou Hasegawa
  • ,
  • Kosuke Kimura
  • ,
  • Masaya Iwamuro
  • ,
  • Yoshihisa Hanayama
  • ,
  • Eisei Kondo
  • ,
  • Nobuaki Miyahara
  • ,
  • Fumio Otsuka

70
3
開始ページ
217
終了ページ
221
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.18926/AMO/54422
出版者・発行元
OKAYAMA UNIV MED SCHOOL

KL-6 is a glycoprotein found predominantly on type II pneumocytes and alveolar macrophages, and often shows increased serum levels in patients with interstitial pneumonia. We report a case of mycobacterium avium complex (MAC) infection whose disease activity was correlated with KL-6 levels in serum. During treatment of rheumatoid arthritis (RA)-associated interstitial lung disease (ILD) with prednisolone, chest image findings improved in association with decreased KL-6 levels. Following tapering of prednisolone, chest image findings deteriorated again as levels of KL-6 increased, suggesting recurrence of RA-ILD. Bronchoscopic examination revealed active MAC infection. Treatment of MAC infection not only improved chest image findings but also decreased KL-6 levels in serum, suggesting that KL-6 was increased by active MAC infection by itself, not by recurrence of RA-ILD. To the best of our knowledge, this is the first documentation of KL-6 elevation in serum in association with active MAC infection.

Web of Science ® 被引用回数 : 2

リンク情報
DOI
https://doi.org/10.18926/AMO/54422
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000379406100010&DestApp=WOS_CPL
URL
http://www.scopus.com/inward/record.url?eid=2-s2.0-84984851135&partnerID=MN8TOARS
URL
http://orcid.org/0000-0003-0995-9405

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