論文

査読有り
2014年12月

POEMS Syndrome in a 20-year-old Patient Diagnosed Following a Complaint of Reduced Visual Acuity

ACTA MEDICA OKAYAMA
  • Shinichiro Doi
  • ,
  • Shuhei Kimura
  • ,
  • Yuki Morizane
  • ,
  • Mika Hosogi
  • ,
  • Mio Hosokawa
  • ,
  • Yusuke Shiode
  • ,
  • Tetsuhiro Kawata
  • ,
  • Eisei Kondo
  • ,
  • Fumio Shiraga

68
6
開始ページ
379
終了ページ
383
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.18926/AMO/53028
出版者・発行元
OKAYAMA UNIV MED SCHOOL

We report a case of POEMS syndrome in a 20-year-old patient diagnosed after visiting an eye clinic with a chief complaint of reduced visual acuity. A male university student aged 20 years was referred to our department complaining of blurred vision in both eyes that had persisted for 1 month. He also noted headache, nausea, and paresthesia in the lower extremities around the same time. The visual acuity of his right and left eye was 20/40 and 20/20, respectively. Optic disc edema and serous retinal detachment were present. Brain magnetic resonance imaging showed no intracranial abnormalities, while elevated cerebrospinal fluid pressure, reduced nerve conduction velocity in both lower extremities, hepatosplenomegaly, M proteinemia, high blood VEGF levels, osteoblastic and osteolytic changes in the spine, and atypical plasma cells in bone lesions were noted. From the above findings, the patient was diagnosed with POEMS syndrome. He received high-dose dexamethasone, thalidomide, and radiotherapy on the sacral mass, followed by high-dose melphalan with autologous stem-cell support, and showed subsequent systemic and ophthalmologic improvement. Here, we report the youngest case ever of POEMS syndrome with ocular manifestation. If patients have optic disc edema in both eyes with no intracranial space-occupying lesion, POEMS syndrome should be considered in differential diagnosis, regardless of age.

Web of Science ® 被引用回数 : 3

リンク情報
DOI
https://doi.org/10.18926/AMO/53028
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000346882200009&DestApp=WOS_CPL
URL
http://www.scopus.com/inward/record.url?eid=2-s2.0-84920942522&partnerID=MN8TOARS
URL
http://orcid.org/0000-0003-0995-9405

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