論文

査読有り
2007年10月

Point mutation of K-ras gene in cisplatin-induced lung tumours in A/J mice

LUNG CANCER
  • Akiko Hisamoto
  • ,
  • Eisei Kondo
  • ,
  • Katsuyuki Kiura
  • ,
  • Toshiaki Okada
  • ,
  • Shinobu Hosokawa
  • ,
  • Junko Mimoto
  • ,
  • Nagio Takigawa
  • ,
  • Masahiro Tabata
  • ,
  • Mitsune Tanimoto

58
1
開始ページ
15
終了ページ
20
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.lungcan.2007.05.012
出版者・発行元
ELSEVIER IRELAND LTD

The risks of secondary lung cancer in patients with early stage non-small and small cell lung cancers are estimated to be 1-2% and 2-10% per patient per year, respectively. Surprisingly, the incidence of second primary cancer in Locally advanced non-small cell lung cancer at 10 years, following cisplatin-based chemotherapy with concurrent radiotherapy, increases to 61%. Those patients, on the road to being cured, cannot overtook the possibility of developing a second primary cancer. We developed a second primary Lung cancer model using cisplatin as a carcinogen in A/J mice to screen for chemopreventive agents for a second malignancy. In the primary lung tumour model, 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK), benzo(a)pyrene (Bap), urethane induces specific K-ras mutations in codon 12, codon 12, and codon 61, respectively, in the A/J mice. In this study, we investigated the mechanisms of carcinogenicity by cisplatin in the A/J mice. In the cisplatin-induced tumours, we found no K-ros codon 12 mutation, which is the major mutation induced by NNK or BaP.K-ras gene mutations in codon 13 and codon 61 were found in one tumour (4%) and five tumours (17.8%), respectively. These findings suggest that cisplatin is partially related to K-ras codon 61 mutations, and that the mechanism of carcinogenicity by cisplatin is different from that by NNK or BaP (c) 2007 Elsevier Ireland Ltd. ALL rights reserved.

Web of Science ® 被引用回数 : 11

リンク情報
DOI
https://doi.org/10.1016/j.lungcan.2007.05.012
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000250248600003&DestApp=WOS_CPL
URL
http://www.scopus.com/inward/record.url?eid=2-s2.0-34548477938&partnerID=MN8TOARS
URL
http://orcid.org/0000-0003-0995-9405

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