論文

査読有り
2009年2月

Using CD40-activated B Cells to Efficiently Identify Epitopes of Tumor Antigens

JOURNAL OF IMMUNOTHERAPY
  • Eisei Kondo
  • ,
  • Luise Gryschok
  • ,
  • Joachim L. Schultze
  • ,
  • Michael S. von Bergwelt-Baildon

32
2
開始ページ
157
終了ページ
160
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1097/CJI.0b013e31819031a2
出版者・発行元
LIPPINCOTT WILLIAMS & WILKINS

The rapid development of genomics and proteomics has accelerated the discovery of antigens that play a role in host-tumor interaction and can be potentially targeted in tumor immunotherapy. Several independent approaches to characterize such antigens and identify the relevant epitopes have been developed. However, the detection, expansion, and characterization of antigen-specific T cells are essential steps common to all strategies. Efficient identification of epitopes, in particular in a preclinical setting, is often hampered by lack of significant numbers of antigen presenting cells at sufficient purity that readily expand low-frequency T-cell precursors. Using the cylins as a model family of self-tumor antigens, we show that CD40-activated primary human B cells can be Used very efficiently to identify novel epitopes and characterize Such tumor antigen-specific T cells.

Web of Science ® 被引用回数 : 11

リンク情報
DOI
https://doi.org/10.1097/CJI.0b013e31819031a2
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000263655300007&DestApp=WOS_CPL
URL
http://www.scopus.com/inward/record.url?eid=2-s2.0-63649158209&partnerID=MN8TOARS
URL
http://orcid.org/0000-0003-0995-9405

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