論文

査読有り
2002年10月

High-dose chemotherapy and autologous peripheral blood stem cell transplantation for treatment of unspecified peripheral T-cell lymphoma presented with hepatosplenomegaly and hypercytokinemia syndrome: report of three cases

ANNALS OF HEMATOLOGY
  • J Tsuchiyama
  • ,
  • K Iamjo
  • ,
  • T Yoshino
  • ,
  • N Nanba
  • ,
  • A Toyota
  • ,
  • C Yoshida
  • ,
  • K Fujii
  • ,
  • E Kondo
  • ,
  • K Okazuka
  • ,
  • S Hashimoto
  • ,
  • K Toba
  • ,
  • Fuse, I
  • ,
  • Y Aizawa
  • ,
  • M Harada
  • ,
  • T Tsubota

81
10
開始ページ
588
終了ページ
592
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s00277-002-0526-8
出版者・発行元
SPRINGER-VERLAG

We report here three cases of peripheral T-cell lymphoma unspecified (PTCL-US), which presented with bone marrow infiltration and hepatosplenomegaly and were successfully treated with high-dose chemotherapy (HDCT) and autologous peripheral blood stem cell transplantation (auto-PBSCT). The patients were all characterized by cytokine-induced symptoms such as fever, anasarca, cytopenia, poor general condition, and disseminated intravascular coagulation syndrome. Laboratory data showed extremely high levels of soluble interleukin-2 receptor, beta(2)-microglobulin, and ferritin. All three patients were negative for anti-adult T-cell leukemia antibody. In one patient, hemophagocytosis was revealed by a histological examination of the bone marrow. The International Prognostic Index was high for all three patients, and they all achieved complete remission after the intensive chemotherapy for remission induction. During complete remission, they were treated with HDCT [modified interleukin-converting enzyme regimen] followed by auto-PBSCT. The recovery of hematopoiesis after auto-PBSCT was prompt and sustained engraftment was obtained. No serious adverse effects other than myelosuppression were noted. One patient died due to cerebrovascular disease without relapse 18 months after auto-PBSCT. The other two patients are still alive and have not suffered from relapse. Our observations suggest that auto-PBSCT following HDCT may be an effective and safe therapeutic modality for high-risk PTCL-US patients characterized by hepatosplenomegaly and cytokine-induced syndrome.

Web of Science ® 被引用回数 : 10

リンク情報
DOI
https://doi.org/10.1007/s00277-002-0526-8
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000179780900008&DestApp=WOS_CPL
URL
http://www.scopus.com/inward/record.url?eid=2-s2.0-0036946611&partnerID=MN8TOARS
URL
http://orcid.org/0000-0003-0995-9405

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