論文

査読有り
2002年4月

Lymphomatous polyp of mantle cell type in the duodenum complicated by gastric cancer: a case of trisomy 3 and t(11;14) (q13;q32)

ANNALS OF HEMATOLOGY
  • J Tsuchiyama
  • ,
  • T Yoshino
  • ,
  • K Imajo
  • ,
  • E Kondou
  • ,
  • E Hamada
  • ,
  • Y Tomiyama
  • ,
  • K Toba
  • ,
  • T Furukawa
  • ,
  • Fuse, I
  • ,
  • Y Aizawa
  • ,
  • M Harada
  • ,
  • T Tsubota

81
4
開始ページ
224
終了ページ
227
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s00277-002-0434-y
出版者・発行元
SPRINGER-VERLAG

We experienced a rare case of a lymphomatous polyp of mantle cell type forming a polypoid mass lesion in the duodenum bulbous together with advanced gastric cancer. A total gastrectomy was performed, and the specimen revealed atypical small- to medium-sized lymphoid cells with indented nuclei, which infiltrated the Peyer's patch and formed a nodular mass in the lamina propria and submucosa of the duodenum. The lymphoma cells also infiltrated the lymphoid follicle of the gastric mucosa, spleen, and regional lymph node with a typical mantle zone pattern. Flow cytometric analysis of the single cells of the lymph node and immunohistochemistry of a paraffin-embedded specimen revealed that the lymphoma cells expressed surface CD5, CD19, CD20, an nuclear cyclin D1. Chromosomal analysis of this single cell suspension revealed that these lymphoma cells have trisomy 3 in conjunction with t(11;14)(q13;q32), which is frequently seen in mucosa-associated lymphoid tissue lymphomas (MALToma) in the stomach and is also reported in mantle cell lymphoma as a secondary genetic alteration. Our report suggests that trisomy 3 may be a common chromosomal abnormality in lymphomatous polyps of mantle cell type.

Web of Science ® 被引用回数 : 7

リンク情報
DOI
https://doi.org/10.1007/s00277-002-0434-y
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000175599100010&DestApp=WOS_CPL
URL
http://www.scopus.com/inward/record.url?eid=2-s2.0-0036934849&partnerID=MN8TOARS
URL
http://orcid.org/0000-0003-0995-9405

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