論文

査読有り
2003年6月

Phenotypic analysis of peripheral T/NK cell lymphoma: Study of 408 Japanese cases with special reference to their anatomical sites

PATHOLOGY INTERNATIONAL
  • K Ichimura
  • ,
  • Y Kagami
  • ,
  • R Suzuki
  • ,
  • M Kojima
  • ,
  • T Yoshino
  • ,
  • K Ohshima
  • ,
  • K Koike
  • ,
  • E Kondo
  • ,
  • H Taji
  • ,
  • M Ogura
  • ,
  • Y Morishima
  • ,
  • T Akagi
  • ,
  • T Takahashi
  • ,
  • S Nakamura

53
6
開始ページ
333
終了ページ
344
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1046/j.1440-1827.2003.01479.x
出版者・発行元
BLACKWELL PUBLISHING ASIA

The World Health Organization (WHO) classification of malignant lymphoma presented a list of disease entities well defined by clinical, immunological and genetic features. Therefore, the current diagnosis of peripheral T/NK-cell lymphomas (PTNKLs) essentially requires the inclusion of anatomical sites of disease and phenotypical features. We analyzed 408 Japanese cases of PTNKLs in order to clarify the relationship between anatomical sites of disease and phenotypical features and to translate the functional subsets of T and NK cells into their diagnoses for further understanding lymphomatic biology. The T/NK-cell lymphoma entities were allocated into three categories: (i) cytotoxic memory T-cell and/or NK-cell lymphoma (n = 151) consisting of extranodal NK/T-cell tumors other than mycosis fungoides (MF); (ii) non-cytotoxic memory T-cell lymphoma (n = 142) consisting of nodal and cutaneous tumors such as angioimmunoblastic T-cell lymphoma, adult T-cell lymphoma/leukemia and MF; and (iii) anaplastic lymphoma kinase positive anaplastic large cell lymphoma (n = 110) that has unique features and might be regarded as cytotoxic 'naive' T-cell lymphoma. Overall, these three categories were significantly correlated with age of onset, anatomical sites, the level of expression of cytotoxic molecules and CD45RO, and association with Epstein-Barr virus. This concept might provide a new insight enabling further understanding of the interrelationships among WHO T/NK-cell disease entities.

Web of Science ® 被引用回数 : 22

リンク情報
DOI
https://doi.org/10.1046/j.1440-1827.2003.01479.x
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000183311200001&DestApp=WOS_CPL
URL
http://www.scopus.com/inward/record.url?eid=2-s2.0-10744223976&partnerID=MN8TOARS
URL
http://orcid.org/0000-0003-0995-9405

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