論文

査読有り
2001年8月

CD34(+)-selected autologous peripheral blood stem cell transplantation conditioned with total body irradiation for malignant lymphoma: Increased risk of infectious complications

INTERNATIONAL JOURNAL OF HEMATOLOGY
  • S Maeda
  • ,
  • Y Kagami
  • ,
  • M Ogura
  • ,
  • H Taji
  • ,
  • R Suzuki
  • ,
  • E Kondo
  • ,
  • S Asakura
  • ,
  • T Takeuchi
  • ,
  • K Miura
  • ,
  • M Ando
  • ,
  • S Nakamura
  • ,
  • T Ito
  • ,
  • T Kinoshita
  • ,
  • R Ueda
  • ,
  • Y Morishima

74
2
開始ページ
214
終了ページ
221
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/BF02982008
出版者・発行元
CARDEN JENNINGS PUBL CO LTD

Although high-dose chemotherapy with autologous peripheral blood stem cell transplantation (autoPBSCT) has been shown or confirmed to be an effective treatment for high-risk and relapsed non-Hodgkin's lymphoma (NHL), relapse after autoPBSCT remains a serious problem. In a clinical trial to overcome relapse, we adopted a treatment plan in which PBSCs purified in vitro to CD34(+) cells to deplete tumor cells (CD34(+) autoPBSCT), total body irradiation (TBI) of 1200 cGy, and melphalan,180 mg/m(2), were used as a preconditioning regimen. Eighteen patients with relapsed or high-risk NHL participated in the study. This study compared the incidence of complications following CD34(+) autoPBSCT preconditioned with the TBI regimen (n = 10): the TBI group; CD34(+) autoPBSCT with the non-TBI regimen (n = 8): the non-TBI group; and unselected autoPBSCT with the non-TBI regimen (n = 19): the unselected autoPBSCT control group. After day 30 posttransplantation, 6 of 10 patients treated with the TBI regimen developed 11 infectious complications in total, compared with only 1 of 8 patients treated with the non-TBI regimen and 4 of 19 patients given unselected autoPBSCT. Two fatal complications occurred in the TBI group, but none occurred in the other 2 groups. The CD4(+) lymphocyte count at 1 month posttransplantation was significantly lower in the TB I group than in the unselected autoPBSCT group. These findings suggest that the addition of TBI to the preconditioning regimen for CD34(+) autoPBSCT is associated with an increased incidence of severe infectious complications after transplantation. (C) 2001 The Japanese Society of Hematology.

Web of Science ® 被引用回数 : 4

リンク情報
DOI
https://doi.org/10.1007/BF02982008
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000171256700016&DestApp=WOS_CPL
URL
http://www.scopus.com/inward/record.url?eid=2-s2.0-0035431470&partnerID=MN8TOARS
URL
http://orcid.org/0000-0003-0995-9405

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