論文

査読有り
2001年5月

Association between polymorphisms of folate- and methionine-metabolizing enzymes and susceptibility to malignant lymphoma

BLOOD
  • K Matsuo
  • ,
  • R Suzuki
  • ,
  • N Hamajima
  • ,
  • M Ogura
  • ,
  • Y Kagami
  • ,
  • H Taji
  • ,
  • E Kondoh
  • ,
  • S Maeda
  • ,
  • S Asakura
  • ,
  • S Kaba
  • ,
  • S Nakamura
  • ,
  • M Seto
  • ,
  • Y Morishima
  • ,
  • K Tajima

97
10
開始ページ
3205
終了ページ
3209
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1182/blood.V97.10.3205
出版者・発行元
AMER SOC HEMATOLOGY

Genetic alteration is considered a probable cause of malignant lymphoma. Folate and methionine metabolism play essential roles in DNA synthesis and DNA methylation, and their metabolic pathways might thus affect disease susceptibility. In the present study, 2 polymorphisms were evaluated for a folate metabolic enzyme, methylenetetrahydrofolate reductase (MTHFR), and one was evaluated for methionine synthase (MS). The 2 polymorphisms, MTHFR677 C-->T and MTHFR1298 A-->C, are reported to reduce the enzyme activity, which causes intracellular accumulation of 5,10-methylenetetrahydrofolate and results in a reduced incidence of DNA double-strand breakage. The MS2756 A-->G polymorphism also reduces the enzyme activity and results in the hypomethylation of DNA. To evaluate the association between malignant lymphoma susceptibility and these polymorphisms, hospital-based case-control study was conducted in Aichi Cancer Center. Ninety-eight patients with histologically confirmed lymphoma and 243 control subjects without cancer were evaluated. Unconditional logistic regression analyses revealed a higher susceptibility with the MTHFR677 CC and the MTHFR1298 AA genotypes (odds ratio, 2.26; 95% confidence interval, 1.26-4.02) when those harboring at least one variant allele in either polymorphism of MTHFR were defined as the reference. For the MS polymorphism, the MS2756 GG genotype also showed a higher susceptibility (odds ratio, 3.83; 95% CI, 1.21-12.1) than those with MS2756 AA or AG types. The significance was not altered when these 3 polymorphisms were evaluated in combination, and the results suggest that folate and methionine metabolism play important roles in the occurrence of malignant lymphomas. Further studies to confirm the association and detailed biologic mechanisms are now required. (Blood. 2001;97:3205-3209) (C) 2001 by The American Society of Hematology.

Web of Science ® 被引用回数 : 169

リンク情報
DOI
https://doi.org/10.1182/blood.V97.10.3205
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000170301300038&DestApp=WOS_CPL
URL
http://www.scopus.com/inward/record.url?eid=2-s2.0-0035874520&partnerID=MN8TOARS
URL
http://orcid.org/0000-0003-0995-9405

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