論文

査読有り
1999年6月

Establishment and characterization of a novel ALL-L3 cell line (BALM-18): induction of apoptosis by anti-IgM and inhibition of apoptosis by bone marrow stroma cells

LEUKEMIA RESEARCH
  • Y Matsuo
  • ,
  • A Sugimoto
  • ,
  • A Harashima
  • ,
  • C Nishizaki
  • ,
  • F Ishimaru
  • ,
  • E Kondo
  • ,
  • Y Katayama
  • ,
  • M Harada
  • ,
  • K Orita

23
6
開始ページ
559
終了ページ
568
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/S0145-2126(99)00046-6
出版者・発行元
PERGAMON-ELSEVIER SCIENCE LTD

A human acute lymphoblastic leukemia (ALL) cell line, BALM-18, was established from the peripheral blood specimen of a patient with B cell ALL L3 type (ALL-L3) at diagnosis using bone marrow stroma cells (BST) as feeder cells. The primary leukemia cells did not grow without feeder cells. As with the primary leukemia cells, BALM-18 showed an immunophenotype of Burkitt's lymphoma group I [CD10 +, CD20 +, CD23 -, CD39 -, CD77 +] and carried the t(8;14)(q24;q32) chromosomal abnormality which is highly associated with ALL-L3 and Burkitt's lymphoma. It also revealed a significantly low level of bcl-2 protein. Strikingly, anti-human IgM antibody did induce apoptosis in induction experiments. However, it was reversed by the addition of anti-CD40 antibody or BST cells, whereas the culture supernatant of the stroma cells did not show any effect on the inhibition of apoptosis. BALM-18 may be useful for analyzing both the mechanisms of anti-IgM induced apoptosis and signaling during the inhibition of apoptosis by CD40 or BST cells. (C) 1999 Elsevier Science Ltd. All rights reserved.

Web of Science ® 被引用回数 : 8

リンク情報
DOI
https://doi.org/10.1016/S0145-2126(99)00046-6
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000080503900005&DestApp=WOS_CPL
URL
http://www.scopus.com/inward/record.url?eid=2-s2.0-0032998622&partnerID=MN8TOARS
URL
http://orcid.org/0000-0003-0995-9405

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