2019年12月
Synthesis and evaluation of in vitro bioactivity for polysubstituted N-arylpyrazole derivatives
Arabian Journal of Chemistry
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- 巻
- 12
- 号
- 8
- 開始ページ
- 1908
- 終了ページ
- 1917
- 記述言語
- 英語
- 掲載種別
- 研究論文（学術雑誌）
- DOI
- 10.1016/j.arabjc.2014.12.004
- 出版者・発行元
- ELSEVIER
© 2014 The Authors New polysubstituted N-arylpyrazole derivatives were synthesized from N1-arylsydnone with acetylene and boronic acid, including 2-thiophenyl, 3-thiophenyl, 2-benzo[b]thiophenyl, or dibenzothiophenyl-4-boronic acid, via 1,3-dipolar cycloaddition and Suzuki coupling reaction. Based on the growth inhibitory activity results against lung carcinoma (NCI-H226), nasopharyngeal (NPC-TW01), and T-cell leukemia (Jurkat) cancer cells, compounds 5d and 7d with dibenzothiophenyl bioisostere possessed the significant inhibitory activity for NPC-TW01 (32 μM and 16 μM) and NCI-H226 (16 μM and 8.9 μM), respectively.
- リンク情報
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- DOI
- https://doi.org/10.1016/j.arabjc.2014.12.004
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000504900300011&DestApp=WOS_CPL
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85042783202&origin=inward 本文へのリンクあり
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85042783202&origin=inward
- ID情報
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- DOI : 10.1016/j.arabjc.2014.12.004
- ISSN : 1878-5352
- eISSN : 1878-5379
- SCOPUS ID : 85042783202
- Web of Science ID : WOS:000504900300011