論文

査読有り
2015年12月

Reduced Adult Hippocampal Neurogenesis and Cognitive Impairments following Prenatal Treatment of the Antiepileptic Drug Valproic Acid

STEM CELL REPORTS
  • Berry Juliandi
  • ,
  • Kentaro Tanemura
  • ,
  • Katsuhide Igarashi
  • ,
  • Takashi Tominaga
  • ,
  • Yusuke Furukawa
  • ,
  • Maky Otsuka
  • ,
  • Noriko Moriyama
  • ,
  • Daigo Ikegami
  • ,
  • Masahiko Abematsu
  • ,
  • Tsukasa Sanosaka
  • ,
  • Keita Tsujimura
  • ,
  • Minoru Narita
  • ,
  • Jun Kanno
  • ,
  • Kinichi Nakashima

5
6
開始ページ
996
終了ページ
1009
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.stemcr.2015.10.012
出版者・発行元
CELL PRESS

Prenatal exposure to valproic acid (VPA), an established antiepileptic drug, has been reported to impair postnatal cognitive function in children born to VPA-treated epileptic mothers. However, how these defects arise and how they can be overcome remain unknown. Using mice, we found that comparable postnatal cognitive functional impairment is very likely correlated to the untimely enhancement of embryonic neurogenesis, which led to depletion of the neural precursor cell pool and consequently a decreased level of adult neurogenesis in the hippocampus. Moreover, hippocampal neurons in the offspring of VPA-treated mice showed abnormal morphology and activity. Surprisingly, these impairments could be ameliorated by voluntary running. Our study suggests that although prenatal exposure to antiepileptic drugs such as VPA may have detrimental effects that persist until adulthood, these effects may be offset by a simple physical activity such as running.

Web of Science ® 被引用回数 : 31

リンク情報
DOI
https://doi.org/10.1016/j.stemcr.2015.10.012
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26677766
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000366142900008&DestApp=WOS_CPL

エクスポート
BibTeX RIS