論文

査読有り
2004年12月

Genetic diversity of HIV type 1 in rural eastern Cameroon

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
  • N Ndembi
  • ,
  • J Takehisa
  • ,
  • L Zekeng
  • ,
  • E Kobayashi
  • ,
  • C Ngansop
  • ,
  • EM Songok
  • ,
  • S Kageyama
  • ,
  • T Takemura
  • ,
  • E Ido
  • ,
  • M Hayami
  • ,
  • L Kaptue
  • ,
  • H Ichimura

37
5
開始ページ
1641
終了ページ
1650
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1097/00126334-200412150-00019
出版者・発行元
LIPPINCOTT WILLIAMS & WILKINS

To monitor the presence of genotypic HIV-1 variants circulating in eastern Cameroon, blood samples from 57 HIV-1-infected individuals attending 3 local health centers in the bordering rural villages with Central African Republic (CAR) were collected and analyzed phylogenetically. Out of the 40 HIV-1 strains with positive polymerase chain reaction (PCR) profile for both gag and env-C2V3,12 (30.0%) had discordant subtype or CRF designation: 2 subtype B/A (gag/env), 1 B/CRF01, 2 B/CRF02, 1 CRF01/CRF01.A, 2 CRF11/CRF01, 1 CRF13/A, 1 CRF13/CRF01, 1 CRF13/CRF11, and 1 G/U (unclassified). Twenty-eight strains (70.0%) had concordant subtypes or CRF designation between gag and env: 27 subtype A and 1 F2. Out of the remaining 17 HIV-1 strains negative for PCR with the env-C2V3 primers used, 10 (58.8%) had discordant subtype or CRF, and 7 (41.2%) had concordant one based on gag/pol/env-gp41 analysis. Altogether, a high proportion (22/57, 38.6%) of the isolates were found to be recombinant strains. In addition, an emergence of new forms of HIV-1 strains, such as subtype B/A (gag/env), B/CRF01 and B/CRF02, was identified. The epidemiologic pattern of HIV-1 in eastern Cameroon, relatively low and high prevalence of CRF02 and CRF 11, respectively, was more closely related to those of CAR and Chad than that of other regions of Cameroon, where CRF02 is the most predominant HIV-1 strain. These findings strongly suggest that this part of Cameroon is a potential hotspot of HIV-1 recombination, with a likelihood of an active generation of new forms of HIV-1 variants, though epidemiologic significance of new HIV-1 forms is unknown.

Web of Science ® 被引用回数 : 33

リンク情報
DOI
https://doi.org/10.1097/00126334-200412150-00019
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000225850000019&DestApp=WOS_CPL

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