Eiichiro Mori

Profile Information

Affiliation: Associate Professor / Chair, School of Medicine, Nara Medical University

Degree: M.D.(Nara Medical University)
Ph.D.(Nara Medical University)

Researcher number: 70803659
ORCID iD: https://orcid.org/0000-0003-0945-196X
J-GLOBAL ID: 201801016225159396
researchmap Member ID: B000287669

External link: https://www.mirai-nmu.com

Research Areas

Life sciences / Molecular biology /

Research History

Jun, 2022 - Present

CEO, molmir, Inc.
Feb, 2019 - Present

Vice Director, International Center, Nara Medical University
Jan, 2019 - Present

Associate Professor / Chair, School of Medicine, Nara Medical University
Sep, 2020 - Mar, 2024

Associate Professor, Virtual Human InformatiX Clinic (V-iCliniX), Nara Medical University
Aug, 2017 - Dec, 2018

Associate Professor / Lecturer, School of Medicine, Nara Medical University
Apr, 2017 - Jul, 2017

Assistant Professor, School of Medicine, Nara Medical University
Sep, 2011 - Mar, 2017

Postdoctoral Fellow, University of Texas Southwestern Medical Center
Apr, 2009 - Mar, 2011

Resident, Center for Postgraduate Training, Nara Medical University Hospital

Education

Apr, 2011 - Jul, 2015

Graduate School of Medicine, Nara Medical University
Apr, 2003 - Mar, 2009

Faculty of Medicine, School of Medicine, Nara Medical University

Papers

Conserved loop of a phase modifier endows protein condensates with fluidity

Honoka Kawamukai, Motonori Matsusaki, Takanari Tanimoto, Mai Watabe, Ken Morishima, Shunsuke Tomita, Yoichi Shinkai, Tatsuya Niwa, Taro Mannen, Hiroyuki Kumeta …

Jul 4, 2024
FLASH Effect Is Not Always Induced by Ultra-high Dose-rate Proton Irradiation Under Hypoxic Conditions.

Shinji Nomura, Masatoshi Hasegawa, Nagaaki Kamiguchi, Hideki Gotou, Junichi Inoue, Kazuya Inoue, Hitoshi Yoshimura, Fumiaki Isohashi, Eiichiro Mori

Anticancer research, 44(7) 2973-2979, Jul, 2024
Unique Binding Sites of Uricosuric Agent Dotinurad for Selective Inhibition of Renal Uric Acid Reabsorptive Transporter URAT1.

Kazuki Fujita, Noriyoshi Isozumi, Qiunan Zhu, Masaya Matsubayashi, Tetsuya Taniguchi, Hiroshi Arakawa, Yoshiyuki Shirasaka, Eiichiro Mori, Ikumi Tamai

The Journal of pharmacology and experimental therapeutics, 390(1) 99-107, Jun 21, 2024
Identification of three distinct cell populations for urate excretion in human kidneys

Yoshihiko M. Sakaguchi, Pattama Wiriyasermkul, Masaya Matsubayashi, Masaki Miyasaka, Nau Sakaguchi, Yoshiki Sahara, Minoru Takasato, Kaoru Kinugawa, Kazuma Sugie, Masahiro Eriguchi …

The Journal of Physiological Sciences, 74(1), Jan 2, 2024
[Biological phase separation in neuromuscular diseases].

Noriyoshi Isozumi, Kazuma Sugie, Eiichiro Mori

Rinsho shinkeigaku = Clinical neurology, 63(12) 799-805, Dec 19, 2023
Zinc finger domains bind low-complexity domain polymers

Naohiko Iguchi, Noriyoshi Isozumi, Yoshikazu Hattori, Tomohiro Imamura, Masatomo So, Hitoki Nanaura, Takao Kiriyama, Nobuyuki Eura, Minako Yamaoka, Mari Nakanishi …

Oct 29, 2023
酸素濃度の変化がiPS細胞の骨分化に与える影響とは

岡本公一, 岡村建祐, 稲垣有佐, 内原好信, 齊藤謙一郎, 小川宗宏, 森英一朗, 田中康仁

日本整形外科学会雑誌, 96(8) S1548-S1548, Sep, 2022
Editorial: Biological Phase Separation

Eiichiro Mori, Tony Z. Jia

Frontiers in Genetics, 13 895689, Apr, 2022 Peer-reviewedInvited
C9orf72-Derived Proline:Arginine Poly-Dipeptides Modulate Cytoskeleton and Mechanical Stress Response

Tomo Shiota, Riko Nagata, Sotaro Kikuchi, Hitoki Nanaura, Masaya Matsubayashi, Mari Nakanishi, Shinko Kobashigawa, Noriyoshi Isozumi, Takao Kiriyama, Kazuaki Nagayama …

Frontiers in Cell and Developmental Biology, 10, Mar 23, 2022
温熱応答回復過程におけるユビキチン化の新たな役割

仲川洋介, 桐田忠昭, 森英一朗

Thermal Medicine, 38(1) 27-28, Mar, 2022
Olig2-astrocytes express neutral amino acid transporter SLC7A10 (Asc-1) in the adult brain

Kouko Tatsumi, Kaoru Kinugawa, Ayami Isonishi, Masahiro Kitabatake, Hiroaki Okuda, Shoko Takemura, Tatsuhide Tanaka, Eiichiro Mori, Akio Wanaka

Molecular Brain, 14(1), Dec, 2021
C9orf72-derived arginine-rich poly-dipeptides impede phase modifiers

Hitoki Nanaura, Honoka Kawamukai, Ayano Fujiwara, Takeru Uehara, Yuichiro Aiba, Mari Nakanishi, Tomo Shiota, Masaki Hibino, Pattama Wiriyasermkul, Sotaro Kikuchi …

Nature Communications, 12(1), Dec, 2021
Ras-like Gem GTPase induced by Npas4 promotes activity-dependent neuronal tolerance for ischemic stroke.

Hiroo Takahashi, Ryo Asahina, Masayuki Fujioka, Takeshi K Matsui, Shigeki Kato, Eiichiro Mori, Hiroyuki Hioki, Tohru Yamamoto, Kazuto Kobayashi, Akio Tsuboi

Proceedings of the National Academy of Sciences of the United States of America, 118(32), Aug 10, 2021
ヒトiPS細胞の骨分化誘導実験における培養期間がRT-qPCRの適切な参照遺伝子の選択に及ぼす影響についての検討

岡村建祐, 稲垣有佐, 森英一朗, 岡本公一, 内原好信, 小川宗宏, 田中康仁

日本整形外科学会雑誌, 95(8) S1697-S1697, Aug, 2021
低酸素環境下ヒトiPS細胞骨分化誘導実験における逆転写-定量的リアルタイムPCR(RT-qPCR)の最適な参照遺伝子とは何か

岡本公一, 岡村建祐, 稲垣有佐, 内原好信, 杉本啓紀, 齊藤謙一郎, 小川宗宏, 森英一朗, 田中康仁

日本整形外科学会雑誌, 95(8) S1819-S1819, Aug, 2021
Transiently structured head domains control intermediate filament assembly.

Xiaoming Zhou, Yi Lin, Masato Kato, Eiichiro Mori, Glen Liszczak, Lillian Sutherland, Vasiliy O Sysoev, Dylan T Murray, Robert Tycko, Steven L McKnight

Proceedings of the National Academy of Sciences of the United States of America, 118(8), Feb 23, 2021
ヒト多能性幹細胞を用いたドパミン作動性神経を有する脳幹オルガノイドの開発

江浦信之, 松井健, 森英一朗, 杉江和馬

パーキンソン病・運動障害疾患コングレスプログラム・抄録集, 14回 108-108, Feb, 2021
27-Hydroxycholesterol regulates human SLC22A12 gene expression through estrogen receptor action.

Masaya Matsubayashi, Yoshihiko M Sakaguchi, Yoshiki Sahara, Hitoki Nanaura, Sotaro Kikuchi, Arvand Asghari, Linh Bui, Shinko Kobashigawa, Mari Nakanishi, Riko Nagata …

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 35(1) e21262, Jan, 2021
Gene Expression Profiles of Human Cerebral Organoids Identify PPAR Pathway and PKM2 as Key Markers for Oxygen-Glucose Deprivation and Reoxygenation.

Naoki Iwasa, Takeshi K Matsui, Naohiko Iguchi, Kaoru Kinugawa, Naritaka Morikawa, Yoshihiko M Sakaguchi, Tomo Shiota, Shinko Kobashigawa, Mari Nakanishi, Masaya Matsubayashi …

Frontiers in cellular neuroscience, 15 605030-605030, 2021
Single-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoids.

Lisa M Smits, Stefano Magni, Kaoru Kinugawa, Kamil Grzyb, Joachim Luginbühl, Sonia Sabate-Soler, Silvia Bolognin, Jay W Shin, Eiichiro Mori, Alexander Skupin …

Cell and tissue research, 382(3) 463-476, Dec, 2020

Misc.

Regulation of Liquid-Liquid Phase Separation by Molecular Chaperones

川越聡一郎, 川越聡一郎, 森英一朗, 齋尾智英, 齋尾智英

Thermal Medicine, 37(2), 2021
LC-domain misregulation leads to amyotrophic lateral sclerosis and related diseases(和訳中)

Mori Eiichiro, Shiota Tomo, Nanaura Hitoki, Sugie Kazuma

臨床神経学, 59(Suppl.) S252-S252, Nov, 2019
Rapid induction of midbrain-like organoids from human pluripotent stem cells(和訳中)

Nanaura Hitoki, Matsui Takeshi K., Shiota Tomo, Eura Nobuyuki, Mori Eiichiro, Sugie Kazuma

臨床神経学, 59(Suppl.) S374-S374, Nov, 2019
A human cerebral organoid model for ZEB2-deficient Mowat-Wilson syndrome(和訳中)

Eura Nobuyuki, Matsui Takeshi K., Nanaura Hitoki, Shiota Tomo, Mori Eiichiro, Sugie Kazuma

臨床神経学, 59(Suppl.) S385-S385, Nov, 2019
Recapitulation of brain ischemia with human cerebral organoids(和訳中)

Shiota Tomo, Matsui Takeshi K., Eura Nobuyuki, Nanaura Hitoki, Mori Eiichiro, Sugie Kazuma

臨床神経学, 59(Suppl.) S389-S389, Nov, 2019
Human cerebral organoids recapitulate brain formation and genetic developmental disorders(和訳中)

Matsui Takeshi K., Eura Nobuyuki, Nanaura Hitoki, Shiota Tomo, Mori Eiichiro, Sugie Kazuma

臨床神経学, 59(Suppl.) S408-S408, Nov, 2019
ヒト中脳と類似した構造を持つ電気生理学的に活発な脳オルガノイドの誘導(Induction of electrophysiologically-active brain organoids showing human midbrain-specific structure)

Matsui Takeshi Ken, Eura Nobuyuki, Nanaura Hitoki, Shiota Tomo, Saitoh Yasuhiko, Sugie Kazuma, Mori Eiichiro

The Journal of Physiological Sciences, 69(Suppl.1) S222-S222, Jun, 2019
温熱とDNAとの出会い DNA損傷と修復(Heat Meets DNA: DNA Damage and Repair)

仲川洋介, 梶原淳久, 桐田忠昭, 森英一朗

Thermal Medicine, 34(2) 15-22, Jun, 2018
The Oxygen-Rich Postnatal Environment Induces Cardiomyocyte Cell-Cycle Arrest through DNA Damage Response (vol 157, pg 741, 2014)

Bao N. Puente, Wataru Kimura, Shalini A. Muralidhar, Jesung Moon, James F. Amatruda, Kate L. Phelps, David Grinsfelder, Beverly A. Rothermel, Rui Chen, Joseph A. Garcia …

CELL, 157(5) 1243-1243, May, 2014
中性子捕捉療法によって誘導されるDNAligaseIVによって修復されないDNA損傷

近藤夏子, 増永慎一郎, 高橋昭久, 鈴木実, 木梨友子, 櫻井良憲, 森英一朗, 長谷川正俊, 大西武雄, 小野公二

日本放射線影響学会第54回大会, Nov, 2011
中性子捕捉療法によって生じるDNA二本鎖切断(DSB)はDSB修復経路の因子DNA ligase IVによって修復されない

近藤夏子, 増永慎一郎, 鈴木実, 木梨友子, 櫻井良憲, 高橋昭久, 森英一朗, 長谷川正俊, 大西武雄, 小野公二

日本中性子捕捉療法学会第8回学術大会一般演題28 (2011.09.16-17) 徳島, Sep, 2011
二本鎖切断(DSB)修復経路を分子標的とする中性子捕捉療法の増感の検討

近藤夏子, 増永慎一郎, 高橋昭久, 森英一朗, 鈴木実, 木梨友子, 劉勇, 長谷川正俊, 大西武雄, 小野公二

第13回癌治療増感研究シンポジウム, 2011
中性子捕捉療法によって誘導されるDNAリガーゼIV修復不能なDNA損傷

近藤夏子, 増永慎一郎, 高橋昭久, 鈴木実, 森英一朗, 仲川洋介, 小野公二, 長谷川正俊, 大西武雄

第70回日本癌学会学術総会, 2011
Irreparable damage for DNA ligase IV induced by BNCT

N.Kondo, S.Masunaga, A.Takahashi, Y.Sakurai, M.Suzuki, Y.Kinashi, E.Mori, K.Ono, M.Hasegawa, T.Ohnishi

6th Young Researchers Boron Neutron Capture Therapy Meeting,, 125-125, 2011
二本鎖切断(DSB)修復経路を分子標的とする中性子捕捉反応効果の増感

近藤夏子, 増永慎一郎, 鈴木実, 木梨友子, 劉勇, ChenYi-Wei, 小野公二, 田中浩基, 櫻井良憲, 丸橋晃 …

京都大学原子炉実験所第45回学術講演会報文集, 163, Jan, 2011
コンピュータによるイメージ加工と温熱誘導γH2AXフォーカスの解析(Computational Image Processing and Analysis of Heat-induced γH2AX Foci)

Somakos Georgios I, 高橋昭久, 森英一朗, 大西武雄

Thermal Medicine, 25(1) 25,(35)-34,(35), Mar, 2009
温熱誘導DNA二本鎖切断の生物学(The Biology of Heat-Induced DNA Double-Strand Breaks)

森英一朗, 高橋昭久, 大西武雄

Thermal Medicine, 24(2) 39,(54)-50,(54), Jun, 2008
Phospho-Nbs1 and Mre11 proteins which recognize DSBs co-localize with γH2AX in the nucleus after heat treatment

Akihisa Takahashi, Eiichiro Mori, Takeo Ohnishi

Annals of Cancer Research and Therapy, 15(2) 50-53, 2007
DNA double strand breaks do not play a role in heat-induced cell killing [1] (multiple letters)

Harm H. Kampinga, Andrei Laszlo, Akihisa Takahashi, Eiichiro Mori, Takeo Ohnishi

Cancer Research, 65(22) 10632-10633, Nov 15, 2005
A possible role of DNA double strand breaks in heat-induced cell killing - In response

A Takahashi, E Mori, T Ohnishi

CANCER RESEARCH, 65(22) 10633-10633, Nov, 2005

Research Projects

Stratification of Protein Aggregation States based on Pattern Recognition for Screening Factors Controlling Phase Separation

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2023 - Mar, 2026
Mechanism of EMT activation of cancer stem cells by phase separation of transcription factors.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2023 - Mar, 2026
New oral cancer treatment strategy targeting PIKK family-related DNA repair mechanisms

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2026
Elucidation of the mechanism of protein homeostasis disruption in autophagy-related neuromuscular diseases

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2025
A novel therapeutic strategy for ischemic stroke based on understanding how subsequently induced Npas4 expression potentiates protecting neurons from death

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2025
機能性素材を応用した血管オルガノイドの作製

科学研究費助成事業, 挑戦的研究(萌芽), 日本学術振興会, Jul, 2021 - Mar, 2023

山城義人, 森英一朗, 吉野大輔
ヒト脳オルガノイドを用いた色素性乾皮症A群患者の進行性神経障害の機構解析

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2020 - Mar, 2023

森俊雄, 森英一朗, 松井健
がん微小環境における頭頸部がん幹細胞のEMTを介した腫瘍免疫抑制と回避の解明

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2020 - Mar, 2023

太田一郎, 高橋昭久, 森英一朗
Regulatory mechanism of biological phase separation

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2023
Suppression of delayed ROS rescue normal human fibroblasts after radiation exposure.

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2023
DNA修復経路と細胞内物質輸送を標的とした口腔がん治療法の開発

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2019 - Mar, 2023

桐田忠昭, 仲川洋介, 森英一朗
A novel therapeutic strategy for ischemic stroke based on reshaping neuronal circuits in an activity-dependent manner

Grants-in-Aid for Scientific Research Challenging Research (Exploratory), Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2019 - Mar, 2022
A novel therapeutic strategy for ischemic stroke based on the activity-dependent transcription factor Npas4

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022
Efficacy of combination of high-LET radiation and anti-VEGF antibody for glioma stem cell control

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2022

Hasegawa Masatoshi
Structural study of LC domains of intermediate filaments

Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity start-up, Grant-in-Aid for Research Activity start-up, Japan Society for the Promotion of Science, Aug, 2017 - Mar, 2019

Mori Eiichiro, Kato Masato

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