Yasushi Enokido - My portal

Profile Information

Affiliation: Medical Research Institute, Tokyo Medical and Dental University

J-GLOBAL ID: 201101082347256130
researchmap Member ID: B000003141

External link: https://nrid.nii.ac.jp/nrid/1000090263326/

Research Interests

Research Areas

Research History

Aug, 2011 - Present

Institute for Developmental Research, Aichi Human Service Center
Jun, 2005 - Jul, 2011

Medical Research Institute, Tokyo Medical and Dental University
Mar, 2002 - May, 2005

室長, 国立精神・神経センター神経研究所遺伝子工学研究部
Apr, 1999 - Feb, 2002

Institute for Protein Research, Osaka University
Oct, 1997 - Mar, 1999

長期フェロー, ヒューマン・フロンティア・サイエンス・プログラム
Apr, 1997 - Sep, 1997

日本学術振興会特定国派遣研究員（英国）
1996 - 1997

Institute for Protein Research, Osaka University
Oct, 1995 - Mar, 1996

Institute for Protein Research, Osaka University

Awards

2017

Outstanding Reviewer, Neurochemistry International 誌

榎戸靖
2007

Best Poster Award, 第6回国際ホモシステイン代謝会議

榎戸靖
2001

奨励賞, 日本神経化学会

榎戸靖
1997

長期フェローシップ, ヒューマン・フロンティア・サイエンス・プログラム

榎戸靖

Papers

Developmental defects and aberrant accumulation of endogenous psychosine in oligodendrocytes in a murine model of Krabbe disease.

Inamura N, Kito M, Go S, Kishi S, Hosokawa M, Asai K, Takakura N, Takebayashi H, Matsuda J, Enokido Y

Neurobiology of disease, 120 51-62, Dec, 2018 Peer-reviewed
The effect of rapamycin, NVP-BEZ235, aspirin, and metformin on PI3K/AKT/mTOR signaling pathway of PIK3CA-related overgrowth spectrum (PROS)

Yasuyo Suzuki, Yasushi Enokido, Kenichiro Yamada, Mie Inaba, Kumiko Kuwata, Naoki Hanada, Tsuyoshi Morishita, Seiji Mizuno, Nobuaki Wakamatsu

ONCOTARGET, 8(28) 45470-45483, Jul, 2017 Peer-reviewed
Niemann-Pick disease type C1 predominantly involving the frontotemporal region, with cortical and brainstem Lewy bodies: An autopsy case

Yoichi Chiba, Hiraku Komori, Shiro Takei, Sanae Hasegawa-Ishii, Noriko Kawamura, Kaori Adachi, Eiji Nanba, Masanori Hosokawa, Yasushi Enokido, Zen Kouchi …

NEUROPATHOLOGY, 34(1) 49-57, Feb, 2014 Peer-reviewed
New aspects of neuronal cell death: Molecular basis of neurodevelopmental and neurodegenerative disorders

Yasushi Enokido

Japanese Journal of Neuropsychopharmacology, 32(1) 31-35, Feb, 2012 Peer-reviewed
Mutant huntingtin impairs Ku70-mediated DNA repair

Yasushi Enokido, Takuya Tamura, Hikaru Ito, Anup Arumughan, Akihiko Komuro, Hiroki Shiwaku, Masaki Sone, Raphaele Foulle, Hirohide Sawada, Hiroshi Ishiguro …

JOURNAL OF CELL BIOLOGY, 189(3) 425-443, May, 2010 Peer-reviewed
Age-dependent change of HMGB1 and DNA double-strand break accumulation in mouse brain

Yasushi Enokido, Ayaka Yoshitake, Hikaru Ito, Hitoshi Okazawa

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 376(1) 128-133, Nov, 2008 Peer-reviewed
Omi/HtrA2 is relevant to the selective vulnerability of striatal neurons in Huntington's disease

Reina Inagaki, Kazuhiko Tagawa, Mei-Ling Qi, Yasushi Enokido, Hikaru Ito, Takuya Tamura, Shigeomi Shimizu, Kityomitsu Oyanagi, Nobutaka Arai, Ichiro Kanazawa …

EUROPEAN JOURNAL OF NEUROSCIENCE, 28(1) 30-40, Jul, 2008 Peer-reviewed
[Disruption of amino acid metabolism in astrocyte and neurological disorders--possible implication of abnormal glia-neuron network in homocystineuria].

Enokido Y

Brain and nerve = Shinkei kenkyu no shinpo, 59(7) 731-737, Jul, 2007 Peer-reviewed
Proteome analysis of soluble nuclear proteins reveals that HMGB1/2 suppress genotoxic stress in polyglutamine diseases

Mei-Ling Qi, Kazuhiko Tagawa, Yasushi Enokido, Natsue Yoshimura, Yo-ichi Wada, Kei Watase, Sho-ichi Ishiura, Ichiro Kanazawa, Juan Botas, Minoru Saitoe …

NATURE CELL BIOLOGY, 9(4) 402-414, Apr, 2007 Peer-reviewed
The induction levels of heat shock protein 70 differentiate the vulnerabilities to mutant huntingtin among neuronal subtypes

Kazuhiko Tagawa, Shigeki Marubuchi, Mei-Ling Qi, Yasushi Enokido, Takuya Tamura, Reina Inagaki, Miho Murata, Ichiro Kanazawa, Erich E. Wanker, Hitoshi Okazawa

JOURNAL OF NEUROSCIENCE, 27(4) 868-880, Jan, 2007 Peer-reviewed
Hepatoma-derived growth factor, a new trophic factor for motor neurons, is up-regulated in the spinal cord of PQBP-1 transgenic mice before onset of degeneration

Shigeki Marubuchi, Tomohiro Okuda, Kazuhiko Tagawa, Yasushi Enokido, Daisuke Horiuchi, Reiko Shimokawa, Takuya Tamura, Mei-Ling Qi, Yoshinobu Eishi, Kazuhiko Watabe …

JOURNAL OF NEUROCHEMISTRY, 99(1) 70-83, Oct, 2006 Peer-reviewed
Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73

M Hoshino, ML Qi, N Yoshimura, T Miyashita, K Tagawa, Y Wada, Y Enokido, S Marubuchi, P Harjes, N Arai …

JOURNAL OF CELL BIOLOGY, 172(4) 589-604, Feb, 2006 Peer-reviewed
Cystathionine beta-synthase is enriched in the brains of Down's patients

A Ichinohe, T Kanaumi, S Takashima, Y Enokido, Y Nagai, H Kimura

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 338(3) 1547-1550, Dec, 2005 Peer-reviewed
Cystathionine beta-synthase, a key enzyme for homocysteine metabolism, is preferentially expressed in the radial glia/astrocyte lineage of developing mouse CNS.

Enokido Y, Suzuki E, Iwasawa K, Namekata K, Okazawa H, Kimura H

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 19(13) 1854-1856, Nov, 2005 Peer-reviewed
Abnormal lipid metabolism in cystathionine beta-synthase-deficient mice, an animal model for hyperhomocysteinemia

K Namekata, Y Enokido, Ishii, I, Y Nagai, T Harada, H Kimura

JOURNAL OF BIOLOGICAL CHEMISTRY, 279(51) 52961-52969, Dec, 2004 Peer-reviewed
MOCA induces membrane spreading by activating Rac1

K Namekata, Y Enokido, K Iwasawa, H Kimura

JOURNAL OF BIOLOGICAL CHEMISTRY, 279(14) 14331-14337, Apr, 2004 Peer-reviewed
Regulation of Bax translocation through phosphorylation at Ser-70 of Bcl-2 by MAP kinase in NO-induced neuronal apoptosis

Y Ishikawa, E Kusaka, Y Enokido, T Ikeuchi, H Hatanaka

MOLECULAR AND CELLULAR NEUROSCIENCE, 24(2) 451-459, Oct, 2003 Peer-reviewed
Upregulation and antiapoptotic role of endogenous Alzheimer amyloid precursor protein in dorsal root ganglion neurons

Nishimura, I, R Takazaki, K Kuwako, Y Enokido, K Yoshikawa

EXPERIMENTAL CELL RESEARCH, 286(2) 241-251, Jun, 2003 Peer-reviewed
Interaction between mutant ataxin-1 and POBP-1 affects transcription and cell death

H Okazawa, T Rich, A Chang, Lin, X, M Waragai, M Kajikawa, Y Enokido, A Komuro, S Kato, M Shibata …

NEURON, 34(5) 701-713, May, 2002 Peer-reviewed

Education

Apr, 1989 - Mar, 1994

生物化学専攻, 理学研究科, 大阪大学大学院
Apr, 1985 - Mar, 1989

School of Science, Osaka University