Papers

Peer-reviewed International journal
Aug 15, 2019

Third Epidemiological Analysis of Nasopharyngeal Carcinoma in the Central Region of Japan from 2006 to 2015.

Cancers
  • Masafumi Kanno
  • Norihiko Narita
  • Yasushi Fujimoto
  • Naohiro Wakisaka
  • Tomokazu Yoshizaki
  • Takeshi Kodaira
  • Chiyoko Makita
  • Yuichiro Sato
  • Keisuke Yamazaki
  • Takanori Wakaoka
  • Yuzo Shimode
  • Hiroyuki Tsuji
  • Ryosuke Kito
  • Hajime Ishinaga
  • Seiji Hosokawa
  • Hiromasa Takakura
  • Kunihiro Nishimura
  • Takuma Matoba
  • Shigeharu Fujieda
  • Display all

Volume
11
Number
8
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.3390/cancers11081180

The present study aimed to clarify the incidence and clinical outcomes of nasopharyngeal carcinoma (NPC) in the Chubu region of Japan from 2006 to 2015, compared with previous reports. A retrospective analysis was conducted based on medical records from 40 hospitals located in the Chubu region in the central Japanese main island, with a population of around 22.66 million individuals. This study was designed in line with to two previous clinical studies into NPC conducted in the same area of Japan. We recruited NPC patients diagnosed in hospitals across this area over a 10-year period (2006-2015) using a questionnaire about sex, age, primary site, clinical symptoms, pathology, Union for International Cancer Control (UICC) staging, serological exam, treatment, and survival. A total of 620 NPC patients were identified. The age-standardized incidence of NPC from 2006 to 2015 was 0.27 per 100,000 individuals per year. There were no significant differences between this study and the previous two studies conducted in the same area of Japan. The five-year overall survival rate for all patients was 75.9%, while those for patients with stages I, II, III, and IVA were 97%, 91%, 79%, and 68%, respectively. The age-standardized annual incidence of NPC in the present study was 0.27 per 100,000 individuals per year, which was relatively low and stable. The five-year overall survival rate for all NPC patients was significantly improved in this decade compared with previous studies. The smoking rates in male and female NPC patients were 64.5% and 18.8%, respectively, thereby suggesting the involvement of smoking in the incidence of NPC.

Link information
DOI
https://doi.org/10.3390/cancers11081180
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31443218
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721521
ID information
  • DOI : 10.3390/cancers11081180
  • Pubmed ID : 31443218
  • Pubmed Central ID : PMC6721521

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