論文

査読有り 国際誌
2017年7月31日

Effects of pulpotomy using mineral trioxide aggregate on prostaglandin transporter and receptors in rat molars.

Scientific reports
  • Naoto Ohkura
  • ,
  • Naoki Edanami
  • ,
  • Ryosuke Takeuchi
  • ,
  • Aiko Tohma
  • ,
  • Mariko Ohkura
  • ,
  • Nagako Yoshiba
  • ,
  • Kunihiko Yoshiba
  • ,
  • Hiroko Ida-Yonemochi
  • ,
  • Hayato Ohshima
  • ,
  • Takashi Okiji
  • ,
  • Yuichiro Noiri

7
1
開始ページ
6870
終了ページ
6870
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s41598-017-07167-y

Mineral trioxide aggregate (MTA) is a commonly used dental pulp-capping material with known effects in promoting reparative dentinogenesis. However, the mechanism by which MTA induces dentine repair remains unclear. The aim of the present study was to investigate the role of prostaglandin E2 (PGE2) in dentine repair by examining the localisation and mRNA expression levels of its transporter (Pgt) and two of its receptors (Ep2 and Ep4) in a rat model of pulpotomy with MTA capping. Ep2 expression was detected in odontoblasts, endothelial cells, and nerve fibres in normal and pulpotomised tissues, whereas Pgt and Ep4 were immunolocalised only in the odontoblasts. Moreover, mRNA expression of Slco2a1 (encoding Pgt), Ptger2 (encoding Ep2), and Ptger4 (encoding Ep4) was significantly upregulated in pulpotomised dental pulp and trigeminal ganglia after MTA capping. Our results provide insights into the functions of PGE2 via Pgt and Ep receptors in the healing dentine/pulp complex and may be helpful in developing new therapeutic targets for dental disease.

リンク情報
DOI
https://doi.org/10.1038/s41598-017-07167-y
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28761141
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537257
ID情報
  • DOI : 10.1038/s41598-017-07167-y
  • PubMed ID : 28761141
  • PubMed Central 記事ID : PMC5537257

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