2014 - 2017
Mechanism of oscillation in the hippocampal microcircuit
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
- Grant number
- 26780411
- Japan Grant Number (JGN)
- JP26780411
- Authorship
- Principal investigator
- Grant amount
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- (Total)
- 3,770,000 Japanese Yen
- (Direct funding)
- 2,900,000 Japanese Yen
- (Indirect funding)
- 870,000 Japanese Yen
- Grant type
- Competitive
The induction mechanism of theta oscillation and gamma oscillation in the hippocampus was examined. Acute hippocampal slices were obtained from mice or rats, and the acetylcholine receptor agonist carbachol was perfused to induce theta oscillation. Electrophysiological recordings were carried out in hippocampal CA3 pyramidal neurons. Stable theta oscillation was induced by carbachol at a perfusion temperature of 33-35℃. In some cases, transient gamma oscillation was also induced during a theta oscillation cycle. Carbachol-induced gamma oscillation was suppressed by a kainite-type glutamate receptor blocker.
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- ID information
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- Grant number : 26780411
- Japan Grant Number (JGN) : JP26780411