Matsubara Etsuro

J-GLOBAL         Last updated: Jul 12, 2019 at 17:39
 
Avatar
Name
Matsubara Etsuro
E-mail
etsurooita-u.ac.jp
Affiliation
Oita University
Section
Faculty of Medicine

Research Interests

 
 

Research Areas

 
 

Published Papers

 
Modifiable Lifestyle Factors and Cognitive Function in Older People: A Cross-Sectional Observational Study
Kimura N, Aso Y, Yabuuchi K, Ishibashi M, Hori D, Sasaki Y, Nakamichi A, Uesugi S, Fujioka H, Iwao S, Jikumaru M, Katayama T, Sumi K, Eguchi A, Nonaka S, Kakumu M, Matsubara E.
Front Neurol.   10 410   Apr 2019   [Refereed]
Comparison of brain perfusion patterns in dementia with Lewy bodies patients with or without cingulate island sign.
Ishibashi M, Kimura N, Sumi K, Aso Y, Matsubara E.
Geriatr Gerontol Int.   19(3) 197-202   Mar 2019   [Refereed]
Melatonin Treatment Enhances Aβ Lymphatic Clearance in a Transgenic Mouse Model of Amyloidosis.
Pappolla MA, Matsubara E, Vidal R, Pacheco-Quinto J, Poeggeler B, Zagorski M, Sambamurti K.
Curr Alzheimer Res   15(7) 637-642   Aug 2018   [Refereed]
Aso Y, Chikazawa R, Kimura Y, Kimura N, Matsubara E
BMC neurology   18(1) 119   Aug 2018   [Refereed]
Ishibashi M, Kimura N, Aso Y, Matsubara E
Clinical neurology and neurosurgery   168 7-11   May 2018   [Refereed]
Abe Y, Kimura N, Takahashi R, Gotou M, Mizukami K, Uchida H, Matsubara E
Geriatrics & gerontology international   17(11) 1907-1913   Nov 2017   [Refereed]
Kamiyama N, Soma R, Hidano S, Watanabe K, Umekita H, Fukuda C, Noguchi K, Gendo Y, Ozaki T, Sonoda A, Sachi N, Runtuwene LR, Miura Y, Matsubara E, Tajima S, Takasaki T, Eshita Y, Kobayashi T
Antiviral research   146 1-11   Oct 2017   [Refereed]
Himeno T, Kuriyama M, Takemaru M, Kanaya Y, Shiga Y, Takeshima S, Takamatsu K, Shimoe Y, Fukushima T, Matsubara E
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association   26(10) 2272-2278   Oct 2017   [Refereed]
Shimada H, Shoji M, Ikeuchi T, Suzuki K, Senda M, Ishii K, Matsuda H, Iwata A, Ihara R, Iwatsubo T, Mutoh K, Nakazawa E, Sekijima Y, Mori E, Ikeda M, Ikeda M, Kawakatsu S, Nakanishi A, Hashimoto M, Nunomura A, Matsubara E, Fukui M, Shirato T, Hirai K, Sakamoto M, Fujii H, Mori H
Brain and nerve = Shinkei kenkyu no shinpo   69(7) 701-709   Jul 2017   [Refereed]
Furukawa K, Tomita N, Uematsu D, Okahara K, Shimada H, Ikeda M, Matsui T, Kozaki K, Fujii M, Ogawa T, Umegaki H, Urakami K, Nomura H, Kobayashi N, Nakanishi A, Washimi Y, Yonezawa H, Takahashi S, Kubota M, Wakutani Y, Ito D, Sasaki T, Matsubara E, Une K, Ishiki A, Yahagi Y, Shoji M, Sato H, Terayama Y, Kuzuya M, Araki N, Kodama M, Yamaguchi T, Arai H
Geriatrics & gerontology international   17(2) 211-218   Feb 2017   [Refereed]
Aso Y, Nakamura K, Kimura N, Takemaru M, Arakawa R, Fujiki M, Hirano T, Kumamoto T, Matsubara E
Pathobiology : journal of immunopathology, molecular and cellular biology   84(1) 25-37   2017   [Refereed]
Hanaoka T, Kimura N, Aso Y, Takemaru M, Kimura Y, Ishibashi M, Matsubara E
Geriatrics & gerontology international   16(7) 836-842   Jul 2016   [Refereed]
Abe Y, Kimura N, Goto M, Aso Y, Matsubara E
Dementia and geriatric cognitive disorders extra   6(1) 133-141   Jan 2016   [Refereed]
Kayano M, Higaki S, Satoh JI, Matsumoto K, Matsubara E, Takikawa O, Niida S.
Biomarker Research   4(22) 22   2016   [Refereed]
Hirakawa H, Terao T, Ninomiya T, Amano Y, Aso Y, Matsubara E
The primary care companion for CNS disorders   17(5)    2015   [Refereed]
Haji M, Kimura N, Hanaoka T, Aso Y, Takemaru M, Hirano T, Matsubara E
Dementia and geriatric cognitive disorders   39(5-6) 360-367   2015   [Refereed]
Amano Y, Kimura N, Hanaoka T, Aso Y, Hirano T, Murai H, Satoh K, Matsubara E
Prion   9(1) 29-33   2015   [Refereed]
Pappolla M, Sambamurti K, Vidal R, Pacheco-Quinto J, Poeggeler B, Matsubara E.
Neurobiology of Disease   71C 215-219   Nov 2014   [Refereed]
Miyashita A, Wen Y, Kitamura N, Matsubara E, Kawarabayashi T, Shoji M, Tomita N, Furukawa K, Arai H, Asada T, Harigaya Y, Ikeda M, Amari M, Hanyu H, Higuchi S, Nishizawa M, Suga M, Kawase Y, Akatsu H, Imagawa M, Hamaguchi T, Yamada M, Morihara T, Takeda M, Takao T, Nakata K, Sasaki K, Watanabe K, Nakashima K, Urakami K, Ooya T, Takahashi M, Yuzuriha T, Serikawa K, Yoshimoto S, Nakagawa R, Saito Y, Hatsuta H, Murayama S, Kakita A, Takahashi H, Yamaguchi H, Akazawa K, Kanazawa I, Ihara Y, Ikeuchi T, Kuwano R
Journal of Alzheimer's disease : JAD   41(4) 1031-1038   2014   [Refereed]
Abe K, Uchiyama S, Matsubara E, Muramatsu S, Atsuta N, Kitagawa K, Iguchi Y, Ooboshi H, Kaji R, Terao Y
Rinsho shinkeigaku = Clinical neurology   53(11) 1155-1158   2013   [Refereed]
Matsubara E, Takamura A, Okamoto Y, Oono H, Nakata T, Wakasaya Y, Kawarabayashi T, Shoji M.
Biomedicak Research International   984041 984041   2013   [Refereed]
Miyashita A, Koike A, Jun G, Wang LS, Takahashi S, Matsubara E, Kawarabayashi T, Shoji M, Tomita N, Arai H, Asada T, Harigaya Y, Ikeda M, Amari M, Hanyu H, Higuchi S, Ikeuchi T, Nishizawa M, Suga M, Kawase Y, Akatsu H, Kosaka K, Yamamoto T, Imagawa M, Hamaguchi T, Yamada M, Morihara T, Takeda M, Takao T, Nakata K, Fujisawa Y, Sasaki K, Watanabe K, Nakashima K, Urakami K, Ooya T, Takahashi M, Yuzuriha T, Serikawa K, Yoshimoto S, Nakagawa R, Kim JW, Ki CS, Won HH, Na DL, Seo SW, Mook-Jung I, Alzheimer Disease Genetics Consortium., St George-Hyslop P, Mayeux R, Haines JL, Pericak-Vance MA, Yoshida M, Nishida N, Tokunaga K, Yamamoto K, Tsuji S, Kanazawa I, Ihara Y, Schellenberg GD, Farrer LA, Kuwano R
PloS one   8(4) e58618   2013   [Refereed]
Takamura A, Sato Y, Watabe D, Okamoto Y, Nakata T, Kawarabayashi T, Oddo S, Laferla FM, Shoji M, Matsubara E.
Life Science   91(23-24) 1177-1186   Dec 2012   [Refereed]
[Melatonin agonist: a possible disease-modifying agent for Alzheimer's disease].
Matsubara E
Nihon rinsho. Japanese journal of clinical medicine   70(2) 349-352   Feb 2012   [Refereed]
Watanabe M, Adachi Y, Jackson M, Yamamoto-Watanabe Y, Wakasaya Y, Shirahama I, Takamura A, Matsubara E, Kawarabayashi T, Shoji M
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association   21(2) 143-145   Feb 2012   [Refereed]
Molecular mechanism underlying Aβ immunotherapy: implications for the toxic action of Aβ oligomers.
Matsubara Etsuro
Journal of Gerontology Geriatrics Research   1(4)    2012   [Refereed]
[Neurological findings leading up to the diagnosis].
Matsubara E
Nihon rinsho. Japanese journal of clinical medicine   69 Suppl 8 305-307   Oct 2011   [Refereed]
Takamura A, Kawarabayashi T, Yokoseki T, Shibata M, Morishima-Kawashima M, Saito Y, Murayama S, Ihara Y, Abe K, Shoji M, Michikawa M, Matsubara E
Journal of neuroscience research   89(6) 815-821   Jun 2011   [Refereed]
Wakasaya Y, Kawarabayashi T, Watanabe M, Yamamoto-Watanabe Y, Takamura A, Kurata T, Murakami T, Abe K, Yamada K, Wakabayashi K, Sasaki A, Westaway D, Hyslop PS, Matsubara E, Shoji M
Journal of neuroscience research   89(4) 576-584   Apr 2011   [Refereed]
Matsubara Etsuro
Molecular Neurodegeneration   6(20) 20   Mar 2011   [Refereed]
Matsubara Etsuro
Journal of Neuroscience Research   89 815-821   2011   [Refereed]
Seino Y, Kawarabayashi T, Wakasaya Y, Watanabe M, Takamura A, Yamamoto-Watanabe Y, Kurata T, Abe K, Ikeda M, Westaway D, Murakami T, Hyslop PS, Matsubara E, Shoji M
Journal of neuroscience research   88(16) 3547-3554   Dec 2010   [Refereed]
Yamamoto-Watanabe Y, Watanabe M, Jackson M, Akimoto H, Sugimoto K, Yasujima M, Wakasaya Y, Matsubara E, Kawarabayashi T, Harigaya Y, Lyndon AR, Shoji M
Brain research   1361 140-145   Nov 2010   [Refereed]
Yamamoto-Watanabe Y, Watanabe M, Okamoto K, Fujita Y, Jackson M, Ikeda M, Nakazato Y, Ikeda Y, Matsubara E, Kawarabayashi T, Shoji M
Journal of the neurological sciences   296(1-2) 59-63   Sep 2010   [Refereed]
[Biological marker for Alzheimer's disease].
Matsubara E
Brain and nerve = Shinkei kenkyu no shinpo   62(7) 769-775   Jul 2010   [Refereed]
Yamamoto-Watanabe Y, Watanabe M, Hikichi M, Ikeda Y, Jackson M, Wakasaya Y, Matsubara E, Kawarabayashi T, Kannari K, Shoji M
Internal medicine (Tokyo, Japan)   49(22) 2409-2414   2010   [Refereed]
Ikeda M, Kawarabayashi T, Harigaya Y, Sasaki A, Yamada S, Matsubara E, Murakami T, Tanaka Y, Kurata T, Wuhua X, Ueda K, Kuribara H, Ikarashi Y, Nakazato Y, Okamoto K, Abe K, Shoji M
Brain research   1250 232-241   Jan 2009   [Refereed]
Wati H, Kawarabayashi T, Matsubara E, Kasai A, Hirasawa T, Kubota T, Harigaya Y, Shoji M, Maeda S
Brain pathology (Zurich, Switzerland)   19(1) 48-57   Jan 2009   [Refereed]
Wakasaya Y, Watanabe M, Tomiyama M, Suzuki C, Jackson M, Fujimuro M, Kimura T, Seino Y, Kawarabayashi T, Yamamoto-Watanabe Y, Matsubara E, Shirahama I, Takamura A, Nakahata N, Shoji M
Internal medicine (Tokyo, Japan)   48(15) 1311-1313   2009   [Refereed]
[Neurotoxic Abeta oligomers: molecular basis for Alzheimer's disease].
Matsubara E
Rinsho shinkeigaku = Clinical neurology   48(11) 906   Nov 2008   [Refereed]
Xu W, Kawarabayashi T, Matsubara E, Deguchi K, Murakami T, Harigaya Y, Ikeda M, Amari M, Kuwano R, Abe K, Shoji M
Brain research   1219 169-179   Jul 2008   [Refereed]
Sasaki A, Kawarabayashi T, Murakami T, Matsubara E, Ikeda M, Hagiwara H, Westaway D, George-Hyslop PS, Shoji M, Nakazato Y
Brain research   1214 159-168   Jun 2008   [Refereed]
Watanabe M, Monai N, Jackson M, Yamamoto-Watanabe Y, Ikeda Y, Suzuki C, Tomiyama M, Kawarabayashi T, Kimura T, Seino Y, Wakasaya Y, Miki Y, Matsubara E, Shoji M
Internal medicine (Tokyo, Japan)   47(24) 2179-2182   2008   [Refereed]
Miyashita A, Arai H, Asada T, Imagawa M, Matsubara E, Shoji M, Higuchi S, Urakami K, Kakita A, Takahashi H, Toyabe S, Akazawa K, Kanazawa I, Ihara Y, Kuwano R, Japanese Genetic Study Consortium for Alzeheimer's Disease.
Human molecular genetics   16(23) 2854-2869   Dec 2007   [Refereed]
Kurata T, Kawarabayashi T, Murakami T, Miyazaki K, Morimoto N, Ohta Y, Takehisa Y, Nagai M, Ikeda M, Matsubara E, Westaway D, Hyslop PS, Harigaya Y, Kamiya T, Shoji M, Abe K
Journal of neuroscience research   85(10) 2246-2252   Aug 2007   [Refereed]
Murakami T, Moriwaki Y, Kawarabayashi T, Nagai M, Ohta Y, Deguchi K, Kurata T, Morimoto N, Takehisa Y, Matsubara E, Ikeda M, Harigaya Y, Shoji M, Takahashi R, Abe K
Journal of neurology, neurosurgery, and psychiatry   78(6) 653-654   Jun 2007   [Refereed]
Yamamoto N, Matsubara E, Maeda S, Minagawa H, Takashima A, Maruyama W, Michikawa M, Yanagisawa K
The Journal of biological chemistry   282(4) 2646-2655   Jan 2007   [Refereed]
Murakami T, Paitel E, Kawarabayashi T, Ikeda M, Chishti MA, Janus C, Matsubara E, Sasaki A, Kawarai T, Phinney AL, Harigaya Y, Horne P, Egashira N, Mishima K, Hanna A, Yang J, Iwasaki K, Takahashi M, Fujiwara M, Ishiguro K, Bergeron C, Carlson GA, Abe K, Westaway D, St George-Hyslop P, Shoji M
The American journal of pathology   169(4) 1365-1375   Oct 2006   [Refereed]
Samura E, Shoji M, Kawarabayashi T, Sasaki A, Matsubara E, Murakami T, Wuhua X, Tamura S, Ikeda M, Ishiguro K, Saido TC, Westaway D, St George Hyslop P, Harigaya Y, Abe K
Brain research   1094(1) 192-199   Jun 2006   [Refereed]
Harigaya Y, Tomidokoro Y, Ikeda M, Sasaki A, Kawarabayashi T, Matsubara E, Kanai M, Saido TC, Younkin SG, Shoji M
Neuroscience letters   395(1) 37-41   Feb 2006   [Refereed]
Kawarabayashi T, Matsubara E, Nagano I, Shoji M, Abe K
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics   42(6) 702-707   Nov 2005   [Refereed]
[What causes Abeta amyloidosis in the brain?].
Matsubara E, Yanagisawa K
No to shinkei = Brain and nerve   57(10) 829-838   Oct 2005   [Refereed]
Nagano I, Shiote M, Murakami T, Kamada H, Hamakawa Y, Matsubara E, Yokoyama M, Moritaz K, Shoji M, Abe K
Neurological research   27(7) 768-772   Oct 2005   [Refereed]
Matsubara E, Nagata T, Kageyama Y, Shiote M, Namba R, Nagano I, Shoji M, Abe K
The Tohoku journal of experimental medicine   207(1) 81-85   Sep 2005   [Refereed]
Nakaya Y, Yamane T, Shiraishi H, Wang HQ, Matsubara E, Sato T, Dolios G, Wang R, De Strooper B, Shoji M, Komano H, Yanagisawa K, Ihara Y, Fraser P, St George-Hyslop P, Nishimura M
The Journal of biological chemistry   280(19) 19070-19077   May 2005   [Refereed]
Ikeda M, Shoji M, Kawarai T, Kawarabayashi T, Matsubara E, Murakami T, Sasaki A, Tomidokoro Y, Ikarashi Y, Kuribara H, Ishiguro K, Hasegawa M, Yen SH, Chishti MA, Harigaya Y, Abe K, Okamoto K, St George-Hyslop P, Westaway D
The American journal of pathology   166(2) 521-531   Feb 2005   [Refereed]
[The recent advance of treatment of Parkinson's disease].
Matsubara E
Nihon rinsho. Japanese journal of clinical medicine   62(9) 1725-1728   Sep 2004   [Refereed]
Matsubara E, Sekijima Y, Tokuda T, Urakami K, Amari M, Shizuka-Ikeda M, Tomidokoro Y, Ikeda M, Kawarabayashi T, Harigaya Y, Ikeda S, Murakami T, Abe K, Otomo E, Hirai S, Frangione B, Ghiso J, Shoji M
Neurobiology of aging   25(7) 833-841   Aug 2004   [Refereed]
Kawarabayashi T, Shoji M, Younkin LH, Wen-Lang L, Dickson DW, Murakami T, Matsubara E, Abe K, Ashe KH, Younkin SG
The Journal of neuroscience : the official journal of the Society for Neuroscience   24(15) 3801-3809   Apr 2004   [Refereed]
Ikarashi Y, Harigaya Y, Tomidokoro Y, Kanai M, Ikeda M, Matsubara E, Kawarabayashi T, Kuribara H, Younkin SG, Maruyama Y, Shoji M
Neurobiology of aging   25(4) 483-490   Apr 2004   [Refereed]
Murakami T, Shoji M, Imai Y, Inoue H, Kawarabayashi T, Matsubara E, Harigaya Y, Sasaki A, Takahashi R, Abe K
Annals of neurology   55(3) 439-442   Mar 2004   [Refereed]
Matsubara E, Bryant-Thomas T, Pacheco Quinto J, Henry TL, Poeggeler B, Herbert D, Cruz-Sanchez F, Chyan YJ, Smith MA, Perry G, Shoji M, Abe K, Leone A, Grundke-Ikbal I, Wilson GL, Ghiso J, Williams C, Refolo LM, Pappolla MA, Chain DG, Neria E
Journal of neurochemistry   85(5) 1101-1108   Jun 2003   [Refereed]
Abe K, Murakami T, Matsubara E, Manabe Y, Nagano I, Shoji M
Annals of the New York Academy of Sciences   977 266-272   Nov 2002   [Refereed]
Sasaki A, Shoji M, Harigaya Y, Kawarabayashi T, Ikeda M, Naito M, Matsubara E, Abe K, Nakazato Y
Virchows Archiv : an international journal of pathology   441(4) 358-367   Oct 2002   [Refereed]
Matsubara E, Shoji M, Abe K, Frangione B, Ghiso J
Drug news & perspectives   15(7) 439-444   Sep 2002   [Refereed]
Prat MI, Adamo AM, González SA, Affranchino JL, Ikeda M, Matsubara E, Shoji M, Smith MA, Castaño EM, Morelli L
Neuroscience letters   326(1) 9-12   Jun 2002   [Refereed]
Shoji M, Matsubara E, Murakami T, Manabe Y, Abe K, Kanai M, Ikeda M, Tomidokoro Y, Shizuka M, Watanabe M, Amari M, Ishiguro K, Kawarabayashi T, Harigaya Y, Okamoto K, Nishimura T, Nakamura Y, Takeda M, Urakami K, Adachi Y, Nakashima K, Arai H, Sasaki H, Kanemaru K, Yamanouchi H, Yoshida Y, Ichise K, Tanaka K, Hamamoto M, Yamamoto H, Matsubayashi T, Yoshida H, Toji H, Nakamura S, Hirai S
Neurobiology of aging   23(3) 363-370   May 2002   [Refereed]
Shizuka-Ikeda M, Matsubara E, Ikeda M, Kanai M, Tomidokoro Y, Ikeda Y, Watanabe M, Kawarabayashi T, Harigaya Y, Okamoto K, Maruyama K, Castaño EM, St George-Hyslop P, Shoji M
Biochemical and biophysical research communications   292(2) 571-578   Mar 2002   [Refereed]
[The treatment of Parkinson's disease--adenosine A2A receptor antagonists].
Matsubara E, Shoji M, Abe K
Nihon rinsho. Japanese journal of clinical medicine   60(1) 112-116   Jan 2002   [Refereed]

Misc

 
【実施診療のための最新認知症学-検査・治療・予防・支援-】 アルツハイマー病の先進医療とRegistry DIAN-J研究登録事業
森 啓, 嶋田 裕之, 東海林 幹夫, 池内 健, 鈴木 一詩, 千田 道雄, 石井 賢二, 松田 博史, 岩田 敦, 井原 涼子, 岩坪 威, 武藤 香織, 中澤 栄輔, 関島 良樹, 森 悦朗, 池田 学, 池田 将樹, 川勝 忍, 中西 亜紀, 橋本 衛, 布村 明彦, 松原 悦朗, 福井 充, 白戸 朋代, 平井 香織, 坂本 昌子, 藤井 比佐子, 石井 一成, 西郷 和真
日本臨床   76(増刊1 実施診療のための最新認知症学 検査・治療・予防・支援) 258-265   Jan 2018
【認知症 発症前治療のために解明すべき分子病態は何か?】 (第8章)創薬・発症前治療への挑戦 オリゴマー抗体医療の現状と展望
松原 悦朗
実験医学   35(12) 2155-2158   Aug 2017
アルツハイマー病の抗体医療は、疾患修飾薬として根本治療の可能性を秘めた魅力的な治療法である。本稿で概説するオリゴマー抗体医療は、その標的をアルツハイマー病の発症分子基盤であるAβオリゴマーに設定し、アルツハイマー病を"予防・治療可能な認知症"とすることをめざした分子医療である。(著者抄録)
【あしたのアルツハイマー病治療】 DIAN/DIAN-J/DIAN-TU
嶋田 裕之, 東海林 幹夫, 池内 健, 鈴木 一詩, 千田 道雄, 石井 賢二, 松田 博史, 岩田 淳, 井原 涼子, 岩坪 威, 武藤 香織, 中澤 栄輔, 関島 良樹, 森 悦朗, 池田 学, 池田 将樹, 川勝 忍, 中西 亜紀, 橋本 衛, 布村 明彦, 松原 悦朗, 福井 充, 白戸 朋代, 平井 香織, 坂本 昌子, 藤井 比佐子, 森 啓
BRAIN and NERVE: 神経研究の進歩   69(7) 701-709   Jul 2017
DIAN観察研究は,家族性アルツハイマー病患者のバイオマーカーの変化を明らかにした。われわれは日本においても同様の研究を行うべく,ワシントン大学と交渉し,国際共同研究としてのDIAN-J研究を開始した。しかしそれは米国での基準を満たさなければならず,大きな困難を伴うものであった。米国では2013年からDIAN-TUという治療介入研究が始まっている。2017年からは次期のDIAN-TU研究が始まる予定であり,日本も参加すべく準備中である。(著者抄録)
【バイオマーカー(体液・アミロイド画像)研究の進歩】 網羅的血液miRNA解析による軽度認知障害のバイオマーカー探索
茅野 光範, 檜垣 小百合, 佐藤 準一, 新飯田 俊平, 松本 健治, 松原 悦朗, 滝川 修
Dementia Japan   31(1) 79-85   Jan 2017
アルツハイマー病の大脳白質病変が脳機能および臨床症状に及ぼす影響
木村 成志, 松原 悦朗
BIO Clinica   31(14) 1519-1525   Dec 2016
認知症研究分野におけるMRI、SPECT、PETなどの画像技術の進歩はめざましく、診断や病態解明に大きく貢献してきた。これまで、著者らは、無症候性大脳白質病変(WML)が、認知機能と脳血流量に及ぼす影響を頭部MRIと脳血流SPECT画像を用いて検討し、高齢者ADでは脳室周囲や大脳深部白質に白質病変を高頻度に認め、前頭葉や辺縁系の脳血流低下やMMSEの進行に影響することを明らかにした。さらに、アミロイドPETや髄液中のバイオマーカー測定を用いた研究を進めている。MWLの病的意義の解明は、発症...