2020年10月2日
Sleep-Wake Control by Melanin-Concentrating Hormone (MCH) Neurons: a Review of Recent Findings.
Current neurology and neuroscience reports
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- 巻
- 20
- 号
- 12
- 開始ページ
- 55
- 終了ページ
- 55
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1007/s11910-020-01075-x
- 出版者・発行元
- Springer Science and Business Media LLC
PURPOSE OF THE REVIEW: Melanin-concentrating hormone (MCH)-expressing neurons located in the lateral hypothalamus are considered as an integral component of sleep-wake circuitry. However, the precise role of MCH neurons in sleep-wake regulation has remained unclear, despite several years of research employing a wide range of techniques. We review recent data on this aspect, which are mostly inconsistent, and propose a novel role for MCH neurons in sleep regulation. RECENT FINDINGS: While almost all studies using "gain-of-function" approaches show an increase in rapid eye movement sleep (or paradoxical sleep; PS), loss-of-function approaches have not shown reductions in PS. Similarly, the reported changes in wakefulness or non-rapid eye movement sleep (slow-wave sleep; SWS) with manipulation of the MCH system using conditional genetic methods are inconsistent. Currently available data do not support a role for MCH neurons in spontaneous sleep-wake but imply a crucial role for them in orchestrating sleep-wake responses to changes in external and internal environments.
- リンク情報
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- DOI
- https://doi.org/10.1007/s11910-020-01075-x
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/33006677
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000574461900001&DestApp=WOS_CPL
- URL
- http://link.springer.com/content/pdf/10.1007/s11910-020-01075-x.pdf
- URL
- http://link.springer.com/article/10.1007/s11910-020-01075-x/fulltext.html
- ID情報
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- DOI : 10.1007/s11910-020-01075-x
- ISSN : 1528-4042
- eISSN : 1534-6293
- PubMed ID : 33006677
- Web of Science ID : WOS:000574461900001